Stromal / other tumors
Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 3 April 2015, last major update July 2012
Copyright: (c) 2003-2015, PathologyOutlines.com, Inc.
● Well circumscribed, benign nerve sheath tumor (also called neurilemmoma), much less common (~ 1/50) in stomach than GIST
● 46 year old woman with stomach mass (Case of the Week #347)
● Well circumscribed but not encapsulated, with interlacing bundles of spindle cells and collagen
● Often nuclear pallisading, Verocay bodies, hyalinized vessels
● May have nuclear atypia, inflammatory cells, peripheral cuff of lymphoid aggregates
● No mitotic figures, no skenoid fibers, no epithelioid features
Cuff of inflammation is common
Case of the Week #347:
46 year old woman
● S100 (strong), vimentin
● Often PAS+ needle shaped crystalloids (Am J Surg Pathol 1999;23:431); variable GFAP
● CD34 (may be focally positive), CD117 (Mod Pathol 2003:16;366), DOG1, desmin, actin
End of Stomach > Stromal / other tumors > Schwannoma
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