Stromal / other tumors

Topic Completed: 1 July 2012

Minor changes: 26 April 2019

Copyright: 2003-2019,, Inc.

PubMed Search: gastric schwannoma

Elliot Weisenberg, M.D.
Page views in 2019: 2,053
Page views in 2020 to date: 1,306
Cite this page: Weisenberg E. Schwannoma. website. Accessed August 15th, 2020.
Definition / general
  • Well circumscribed, benign nerve sheath tumor (also called neurilemmoma), much less common (~ 1 / 50) in stomach than GIST
Case reports
Microscopic (histologic) description
  • Well circumscribed but not encapsulated, with interlacing bundles of spindle cells and collagen
  • Often nuclear pallisading, Verocay bodies, hyalinized vessels
  • May have nuclear atypia, inflammatory cells, peripheral cuff of lymphoid aggregates
  • No mitotic figures, no skenoid fibers, no epithelioid features
Microscopic (histologic) images

Contributed by Dr. Pallavi Rao, Sakra World Hospital, Bangalore (India), Case of the Week #455

Microcystic variant of schwannoma in stomach

S100, microcystic variant

CD117, microcystic variant

Contributed by Dr. Jordan Roberts, The Methodist Hospital, Texas (USA), Case of the Week #347

46 year old woman

Positive stains
Negative stains
Board review style question #1
Which of the following describes the majority of schwannomas arising in the gastrointestinal tract?

A. Both encapsulated and circumscribed
B. Circumscribed but not encapsulated
C. Encapsulated but not circumscribed
D. Neither encapsulated nor circumscribed

Board review answer #1
B. Circumscribed but not encapsulated

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