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Stomach

Stromal / other tumors

Schwannoma

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 13 October 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Well circumscribed, benign nerve sheath tumor (also called neurilemmoma), much less common (~ 1/50) in stomach than GIST

Micro description
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● Well circumscribed but not encapsulated, with interlacing bundles of spindle cells and collagen
● Often nuclear pallisading, Verocay bodies, hyalinized vessels
● May have nuclear atypia, inflammatory cells, peripheral cuff of lymphoid aggregates
● No mitotic figures, no skenoid fibers, no epithelioid features

Micro images
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Cuff of inflammation is common

Positive stains
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● S100 (strong), vimentin
● Often PAS+ needle shaped crystalloids (Am J Surg Pathol 1999;23:431); variable GFAP

Negative stains
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● CD34 (may be focally positive), CD117 (Mod Pathol 2003:16;366), DOG1, desmin, actin

End of Stomach > Stromal / other tumors > Schwannoma

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