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Staging neuroendocrine tumors

Reviewer: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 13 October 2012, last major update July 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

Primary tumor (T)

TX: Primary tumor cannot be assessed
T0: No evidence of primary tumor
Tis: Carcinoma in situ / dysplasia (tumor size less than 0.5 mm), confined to mucosa
T1: Tumor invades lamina propria or submucosa and 1 cm or less in size
T2: Tumor invades muscularis propria or more than 1 cm in size
T3: Tumor penetrates subserosa
T4: Tumor invades visceral peritoneum (serosal) or other organs or adjacent structures

Note: For any T, add (m) for multiple tumors

Regional lymph nodes (N)

NX: Regional lymph nodes cannot be assessed
N0: No regional lymph node metastasis
N1: Regional lymph node metastasis

Distant Metastasis (M)

M0: No distant metastasis
M1: Distant metastasis

Anatomic stage / prognostic groups

Stage 0: Tis N0 M0
Stage I: T1 N0 M0
Stage IIA: T2 N0 M0
Stage IIB: T3 N0 M0
Stage IIIA: T4 N0 M0
Stage IIIB: Any T N1 M0
Stage IV: M1 (any T, any N)

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