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Stomach

Other non-neoplastic lesions

Xanthoma

Reviewers: Elliot Weisenberg, M.D. (see Reviewers page)
Revised: 4 August 2012, last major update August 2012
Copyright: (c) 2003-2012, PathologyOutlines.com, Inc.

General
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● Also known as xanthelasma, lipid islands
● Common in Japan
● May be due to bile reflux
● No clinical significance

Case reports
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● Xanthoma and hyperplastic gastric polyposis (Arch Pathol Lab Med 1989;113:428)

Gross description
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● Small yellow / cream colored intramucosal lesion, < 5 mm, single or multiple

Micro description
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● Foamy histiocytes with neutral fat in the lamina propria

Negative stains
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● PAS

Differential diagnosis
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● Signet ring carcinoma

Additional references
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● Odze RD, Goldblum JR (2009). Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas. Philadelphia, PA: Saunders
● Fenoglio-Preiser CM, Noffsinger AE, Stemmermann GN (2007). Gastrointestinal Pathology: an atlas and text. Philadelphia, PA: Lippincott Williams & Wilkins

End of Stomach > Other non-neoplastic lesions > Xanthoma

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