Testis and epididymis
Nonneoplastic testicular lesions
Chemotherapy effect

Author: Sean Williamson, M.D. (see Authors page)

Revised: 6 April 2017, last major update December 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: testicular lesions Chemotherapy effect

Table of Contents
Definition / general
Cite this page: Chemotherapy effect. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testischemotherapy.html. Accessed October 16th, 2018.
Definition / general
  • Dose related changes to seminiferous tubules occur due to alkylating agents, may cause germ cell aplasia
  • After cyclophosphamide, patients become azoospermic until 15 - 49 months after therapy ceases; spermatogenesis may not return in some with germ cell aplasia
  • Tubules are also damaged by methotrexate for psoriasis, Ara-C for ALL, DBCP exposure in petrochemical workers