Table of ContentsDefinition / general
Cite this page: Williamson S. Chemotherapy effect. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testischemotherapy.html. Accessed May 23rd, 2019.
Definition / general
- Dose related changes to seminiferous tubules occur due to alkylating agents, may cause germ cell aplasia
- After cyclophosphamide, patients become azoospermic until 15 - 49 months after therapy ceases; spermatogenesis may not return in some with germ cell aplasia
- Tubules are also damaged by methotrexate for psoriasis, Ara-C for ALL, DBCP exposure in petrochemical workers