Testis and epididymis
Nonneoplastic lesions
Chemotherapy effect




Topic Completed: 1 December 2012

Revised: 27 March 2019

Copyright: 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: testicular lesions Chemotherapy effect

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Table of Contents
Definition / general
Cite this page: Williamson S. Chemotherapy effect. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testischemotherapy.html. Accessed May 23rd, 2019.
Definition / general
  • Dose related changes to seminiferous tubules occur due to alkylating agents, may cause germ cell aplasia
  • After cyclophosphamide, patients become azoospermic until 15 - 49 months after therapy ceases; spermatogenesis may not return in some with germ cell aplasia
  • Tubules are also damaged by methotrexate for psoriasis, Ara-C for ALL, DBCP exposure in petrochemical workers
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