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Table of Contents
Definition / general | Epidemiology | Sites | Pathophysiology | Radiology description | Radiology images | Prognostic factors | Case reports | Treatment | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Molecular / cytogenetics description | Differential diagnosisCite this page: Chondrosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testischondrosarcoma.html. Accessed July 15th, 2017.
Definition / general
- Malignant extraskeletal cartilage forming tumor arising from germ cell tumor (teratoma)
Epidemiology
- Young men with germ cell tumors that have a component of teratoma
- Age range 19 - 40 years
Sites
- Testis, retroperitoneum
Pathophysiology
- Malignant transformation of cartilaginous component of teratoma
Radiology description
- Testicular ultrasound is imaging modality of choice for a scrotal mass (Semin Ultrasound CT MR 2013;34:257, Gordetsky: Gordo's Guide to GU Pathology [Ch 7, pg 190-192, 204])
- CT or MRI can detect retroperitoneal masses, consistent with metastatic teratoma (Semin Ultrasound CT MR 2013;34:257)
- Nonseminomatous germ cell tumors appear as heterogeneous masses with necrosis, hemorrhage, cystic degeneration, fat or calcifications (Radiographics 2004;24:387)
Radiology images
Images hosted on other servers:
MR image
CT scan
Prognostic factors
- Strongest predictors of long survival are stage at presentation and feasibility to perform radical excision (Int J Surg Pathol 2011;19:321)
- Secondary malignant component within a germ cell tumor rarely occurs and overall has a poor prognosis
Case reports
- 24 year old man with 2.5 cm i(12p) testicular tumor with metastases to retroperitoneal lymph nodes (Am J Surg Pathol 1993;17:738)
- 37 year old man with chondrosarcoma in recurrent retroperitoneal mass after chemotherapy for testicular germ cell tumor (Urol Int 2006;77:86)
- 40 year old man with 3 year history of right testis mass (Int Braz J Urol 2003;29:522)
Treatment
- Surgical excision if feasible
- Less sensitive to chemotherapy
Gross description
- Gray to tan, firm, lobulated mass
Microscopic (histologic) description
- Tumor cells produce cartilaginous matrix; either well, moderate or poorly differentiated
- Well differentiated lesions are less cellular with few binucleated cells and mild to moderate atypia
- Tend to have a lobulated architecture with abundant cartilaginous matrix separated by narrow fibrovascular bands
Microscopic (histologic) images
Images hosted on other servers:
Grade 1
Abundant blue chondroid matrix
Lobular growth pattern
Plump, hyperchromatic nuclei
Atypical chondrocytes
Grade 2
Grade 3
Molecular / cytogenetics description
- Somatic type malignancies that develop in germ cell tumors tend to have the same genetic alterations, detectable by FISH and loss of heterozygosity studies, as in the corresponding teratoma
- 12p overexpression and i(12p) has been reported (Am J Surg Pathol 2012;36:1849, Am J Surg Pathol 1993;17:738)
Differential diagnosis
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