Testis and epididymis

Author: Rafael Jimenez, M.D. (see Authors page)

Revised: 23 June 2017, last major update March 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Epididymis [title] normal

Cite this page: Epididymis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testisepidnormal.html. Accessed October 20th, 2018.
Definition / general
  • Connects efferent ductules to vas deferens
  • Has head, body and tail
  • Composed of columnar cells (tall, ciliated with PAS+ nuclear inclusions), clear cells and basal contractile cells (actin positive)
  • May have "monster" cells similar to seminal vesicle (no significance, Am J Surg Pathol 1981;5:483)
  • Tubules have thick muscular coat
  • References: Am J Surg Pathol 2003;27:469
  • Nonpathologic morphologic variations:
    • Intranuclear eosinophilic inclusions: 72%, usually older patients
    • Lipofuscin pigment: 33% usually in efferent ducts and associated with obstructive changes
    • Cribriform hyperplasia: 42% usually NOT in normal testis
    • Paneth cell-like metaplasia: 8% with hyalin-like globules that are positive for PAS with and without diastase digestion, associated with obstructive changes
    • Nuclear atypia: 14% similar to that in seminal vesicles, associated with older age
    • Note: rarely present within hernia sacs (Am J Surg Pathol 1999;23:880)
    • References: Am J Surg Pathol 1998;22:990
Diagrams / tables

Images hosted on other servers:

Right testis

Section of epididymis of guinea pig

Microscopic (histologic) images

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Various images


Positive stains