Testis and epididymis
Nonneoplastic lesions
Spermatic granuloma (epididymitis nodosa)

Author: Rafael Jimenez, M.D. (see Authors page)

Revised: 5 June 2017, last major update March 2012

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PubMed Search: Spermatic granuloma[title]
Cite this page: Spermatic granuloma (epididymitis nodosa). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testisepidspermgran.html. Accessed July 22nd, 2017.
Definition / general
  • Resembles vasitis nodosa
  • Causes: inflammation or trauma damage epithelium or basement membrane, causing spillage of spermatozoa into interstitium (similar to vasitis nodosa) and resulting granulomatous inflammation
  • References: Arch Pathol Lab Med 1986;110:61
Gross description
  • Nodule up to 3 cm in head of epididymis
Microscopic (histologic) description
  • Noncaseating granulomas around spermatozoa
Differential diagnosis