Testis and epididymis
Nonneoplastic lesions
Granulomatous ischemic lesion

Author: Rafael Jimenez, M.D. (see Authors page)

Revised: 8 June 2017, last major update March 2012

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PubMed Search: granulomatous ischemic lesion
Cite this page: Granulomatous ischemic lesion. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testisgranischemic.html. Accessed October 22nd, 2018.
Definition / general
  • Usually affects head of epididymis
  • May be due to ischemia with secondary granulomatous reaction and scarring
  • References: (Am J Surg Pathol 1997;21:951)
Microscopic (histologic) description
  • Zone of necrosis involving efferent ducts and interstitial connective tissue, with adjacent lymphocytes and macrophages
  • Macrophages form large clusters with cholesterol crystals and foreign body type giant cells in duct lumen
  • Also intratubular epithelial regeneration and proliferation of small ducts showing epithelial regeneration and numerous spermatozoa in their lumen
  • Associated with ceroid granuloma, spermatic granuloma and epidermoid metaplasia of the efferent ducts