Granulomatous ischemic lesion

Testis and epididymis
Nonneoplastic lesions
Granulomatous ischemic lesion

Author: Rafael Jimenez, M.D. (see Authors page)

Revised: 8 June 2017, last major update March 2012

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PubMed Search: granulomatous ischemic lesion

Table of Contents

Definition / general | Microscopic (histologic) description

Cite this page: Granulomatous ischemic lesion. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testisgranischemic.html. Accessed July 15th, 2017.

Definition / general

Usually affects head of epididymis
May be due to ischemia with secondary granulomatous reaction and scarring
References: (Am J Surg Pathol 1997;21:951)

Microscopic (histologic) description

Zone of necrosis involving efferent ducts and interstitial connective tissue, with adjacent lymphocytes and macrophages
Macrophages form large clusters with cholesterol crystals and foreign body type giant cells in duct lumen
Also intratubular epithelial regeneration and proliferation of small ducts showing epithelial regeneration and numerous spermatozoa in their lumen
Associated with ceroid granuloma, spermatic granuloma and epidermoid metaplasia of the efferent ducts