Granulomatous orchitis

Testis and epididymis
Nonneoplastic testicular lesions
Granulomatous orchitis

Author: Sean Williamson, M.D. (see Authors page)

Revised: 6 April 2017, last major update December 2012

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PubMed Search: Granulomatous orchitis [title] testicular

Table of Contents

Definition / general | Gross description | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosis

Cite this page: Granulomatous orchitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testisgranulomatousorchitis.html. Accessed July 15th, 2017.

Definition / general

Rare; usually men 40 - 59 years with sudden onset of tender testicular mass, variable fever
May be a response to acid fast products of disintegrated sperm, postinfectious or due to trauma or sarcoidosis
Resembles pyogenic epididymo-orchitis
Benign, although granulomatous inflammation may be associated with seminoma
Recommend cultures to rule out infectious process (brucellosis, leprosy, sarcoidosis, syphilis, TB)

Gross description

Solid, unilateral nodular enlargement of testis; resembles lymphoma

Microscopic (histologic) description

Lymphocytes and plasma cells infiltrate interstitium and surround seminiferous tubules
Giant cells and histiocytes that resemble (but are not) actual granulomas

Microscopic (histologic) images

Images hosted on other servers:

Idiopathic granulomatous orchitis

Distinct granulomas not present

Intratubular infiltrates of epithelioid histiocytes

Differential diagnosis

Granulomatous inflammation associated with seminoma
Infection or inflammation (Hum Pathol 1990;21:1080)
Lymphoma