Testis and epididymis
Nonneoplastic testicular lesions
Granulomatous orchitis

Author: Sean Williamson, M.D. (see Authors page)

Revised: 6 April 2017, last major update December 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Granulomatous orchitis [title] testicular

Cite this page: Granulomatous orchitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testisgranulomatousorchitis.html. Accessed November 21st, 2018.
Definition / general
  • Rare; usually men 40 - 59 years with sudden onset of tender testicular mass, variable fever
  • May be a response to acid fast products of disintegrated sperm, postinfectious or due to trauma or sarcoidosis
  • Resembles pyogenic epididymo-orchitis
  • Benign, although granulomatous inflammation may be associated with seminoma
  • Recommend cultures to rule out infectious process (brucellosis, leprosy, sarcoidosis, syphilis, TB)
Gross description
  • Solid, unilateral nodular enlargement of testis; resembles lymphoma
Microscopic (histologic) description
  • Lymphocytes and plasma cells infiltrate interstitium and surround seminiferous tubules
  • Giant cells and histiocytes that resemble (but are not) actual granulomas
Microscopic (histologic) images

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Idiopathic granulomatous orchitis

Distinct granulomas not present

Intratubular infiltrates of epithelioid histiocytes

Differential diagnosis