Testis and epididymis

Author: Turki Al-Hussain, M.D. (see Authors page)

Revised: 30 November 2018, last major update August 2012

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PubMed Search: Hypospermatogenesis [title] infertility

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Cite this page: Al-Hussain T. Hypospermatogenesis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testishyposperm.html. Accessed January 17th, 2019.
Definition / general
  • All stages of spermatogenesis present but reduced to a varying degree
  • Includes the mixed pattern with some tubules showing Sertoli cells only or hyaline sclerosis with others tubules containing complete spermatogenesis
  • Mild if changes in occasional tubules; severe if significant reductions in all tubules, moderate in between
  • Often is thickening of tunica propria, interstitial fibrosis, tubular sclerosis, germ cell disorganization and sloughing into lumina
  • Many causes of infertility induce hypospermatogenesis, such as diabetes mellitus, toxins, excess heat, varicocele, hypothyroidism, irradiation and others
Microscopic (histologic) images

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Various causes of hypospermatogenesis