Testis and epididymis
Germ cell tumors
Reviewer: Turki Al-Hussain, M.D. (see Reviewers page)
Revised: 21 April 2013, last major update January 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
- Isochromosome 12p or extra 12p seen in almost all germ cell tumors
- Highly specific for germ cell tumors, but also seen in ovarian germ cell neoplasms; occasionally in acute leukemia, embryonal rhabdomyosarcoma, neuroepithelioma
- Chromosome has identical arms, probably from misdivision of centromere
- Extra copies of 12p associated with tumor progression and treatment failure, particularly in non-seminomatous germ cell tumors
- Associated with increased levels of PTH related peptide
End of Testis and epididymis > Germ cell tumors > Isochromosome 12p
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