Isochromosome 12p

Testis and epididymis
Germ cell tumors
Isochromosome 12p

Author: Turki Al-Hussain, M.D. (see Authors page)

Revised: 19 June 2017, last major update January 2013

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed search: Isochromosome 12p[title]

Table of Contents

Definition / general

Cite this page: Isochromosome 12p. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testisiso12p.html. Accessed July 15th, 2017.

Definition / general

Isochromosome 12p or extra 12p seen in almost all germ cell tumors
Highly specific for germ cell tumors but also seen in ovarian germ cell neoplasms; occasionally in acute leukemia, embryonal rhabdomyosarcoma, neuroepithelioma
Chromosome has identical arms, probably from misdivision of centromere
Extra copies of 12p associated with tumor progression and treatment failure, particularly in nonseminomatous germ cell tumors
Associated with increased levels of PTH related peptide