Testis and epididymis
Germ cell tumors
Isochromosome 12p

Author: Turki Al-Hussain, M.D. (see Authors page)

Revised: 19 June 2017, last major update January 2013

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed search: Isochromosome 12p[title]

Table of Contents
Definition / general
Cite this page: Isochromosome 12p. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testisiso12p.html. Accessed September 25th, 2018.
Definition / general
  • Isochromosome 12p or extra 12p seen in almost all germ cell tumors
  • Highly specific for germ cell tumors but also seen in ovarian germ cell neoplasms; occasionally in acute leukemia, embryonal rhabdomyosarcoma, neuroepithelioma
  • Chromosome has identical arms, probably from misdivision of centromere
  • Extra copies of 12p associated with tumor progression and treatment failure, particularly in nonseminomatous germ cell tumors
  • Associated with increased levels of PTH related peptide