Testis and epididymis
Klinefelter syndrome

Author: Turki Al-Hussain, M.D. (see Authors page)

Revised: 4 April 2017, last major update September 2012

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PubMed Search: Klinefelter syndrome [title] infertility

Cite this page: Klinefelter syndrome. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testisklinefelter.html. Accessed November 15th, 2018.
Definition / general
  • 47XXY, reduced body and pubic hair, gynecomastia in 40 - 80%, high FSH, variable LH
  • Increased risk of breast cancer and extragonadal germ cell tumor
Gross description
  • Small, firm testes
Microscopic (histologic) description
  • Reduced number of intratubular germ cells, some tubules are Sertoli cell only
  • Also tubular sclerosis, Leydig cell nodules (appear hyperplastic due to tubular atrophy), focal spermatogenesis rarely seen
Microscopic (histologic) images

Images hosted on other servers:

Small hyalinized seminiferous tubules

Atrophy of seminiferous tubules

Hyalinized seminiferous tubules

Electron microscopy description