Testis and epididymis
Reviewer: Turki Al-Hussain, M.D. (see Reviewers page)
Revised: 15 April 2013, last major update September 2012
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- 47XXY, reduced body and pubic hair, gynecomastia in 40-80%, high FSH, variable LH
- Increased risk of breast cancer and extragonadal germ cell tumor
- Reduced number of intratubular germ cells, some tubules are Sertoli cell only
- Also tubular sclerosis, Leydig cell nodules (appear hyperplastic due to tubular atrophy), focal spermatogenesis rarely seen
Small hyalinized seminiferous tubules
Atrophy of seminiferous tubules
Hyalinized seminiferous tubules
Electron microscopy description
End of Testis and epididymis > Infertility > Klinefelter syndrome
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