Testis and epididymis
Infectious testicular lesions

Author: Sean Williamson, M.D. (see Authors page)

Revised: 5 April 2017, last major update December 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Leprosy [title] testicular

Table of Contents
Definition / General
Cite this page: Leprosy. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testisleprosy.html. Accessed April 27th, 2017.
Definition / General
  • Does not occur in U.S.
  • Rarely presents with orchitis (Am J Clin Pathol 1980;73:712)
  • Testicular involvement thought to be facilitated by lower temperature of scrotum
  • Three phases of testicular involvement:
    1. Vascular phase: blood vessels show perivascular lymphocytic inflammation and interstitium is filled with macrophages containing mycobacteria
    2. Interstitial phase: endarteritis, Leydig cell clusters, interstitial fibrosis, histiocytes containing acid fast bacteria and reduced spermatogenesis
    3. Obliterative phase: dense fibrosis, no detectable tubules, reduced vessels, rare acid fast bacteria; associated with gynecomastia and infertility