Testis and epididymis
Other tumors not specific to testis
Metastases to testes

Topic Completed: 1 December 2013

Revised: 2 May 2019

Copyright: 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Metastases testes [title]

Jennifer Gordetsky, M.D.
Page views in 2018: 394
Page views in 2019 to date: 301
Cite this page: Gordetsky J. Metastases to testes. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testismetastases.html. Accessed September 20th, 2019.
Definition / general
  • Tumors of the testis which neither originate in the testis nor come from direct extension of tumors arising in nontesticular sites
  • Rarely is the first clinical sign of disease
  • Also called secondary tumors of the testis
  • Most often found incidentally at autopsy in patients with known disseminated disease
  • Present as the initial evidence of disease 67% of cases
  • 15 - 20% bilateral
  • Bimodal age distribution:
  • Clinical information and ancillary investigations can be more helpful than special histological techniques in the differential diagnosis
Case reports
Clinical images

Images hosted on other servers:

Bladder metastases to testis:

Enlarged testis with hypervascularity

Abdominal para-aortic lymphadenopathy

Left testis with a mixed solid - cystic lesion

Gross description
  • Multinodular or bilateral disease
Gross images

Images hosted on other servers:

Metastatic prostatic adenocarcinoma

Microscopic (histologic) description
  • Metastatic carcinomas tend to infiltrate the testicular interstitium while sparing the seminiferous tubules
  • Rare intratubular growth patterns have been reported
  • Extensive vascular involvement
Microscopic (histologic) images

Images hosted on other servers:

Metastatic prostatic adenocarcinoma: H&E and PSA

Metastatic bladder carcinoma

Positive stains
  • Mucin (teratomatous elements and yolk sac tumors may also be positive)
  • EMA
Negative stains
Molecular / cytogenetics description
  • Detection of isochromosome 12 by fluorescence in situ hybridization would suggest a primary germ cell tumor
Differential diagnosis
Back to top