Testis and epididymis
Nonneoplastic testicular lesions
Nodular periorchitis (paratesticular fibrous pseudotumor)

Author: Sean Williamson, M.D. (see Authors page)

Revised: 10 April 2017, last major update December 2012

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PubMed Search: nodular periorchitis

Cite this page: Nodular periorchitis (paratesticular fibrous pseudotumor). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testisnodulardiffuse.html. Accessed September 25th, 2018.
Definition / general
  • Synonyms: chronic proliferative periorchitis, inflammatory pseudotumor, nodular and diffuse fibrous proliferation, paratesticular fibrous pseudotumor
  • Ages 7 - 95 years, peaks in 20's
  • Reactive fibrous mass, usually between testicular tunica layers; also involves epididymis and spermatic cord, associated with hydrocele, infection, trauma (Am J Surg Pathol 2010;34:569)
  • Some cases may be type of IgG4 associated sclerosing disease (Virchows Arch 2011;458:109, Hum Pathol 2012;43:2084)
Case reports
  • 22 year old man with collagen rich stromal tumor attached to testicular tunica albuginea (Hum Pathol 1990;21:866)
  • Excision
Gross description
  • Multinodular thickening of peritesticular tissue or discrete mass of firm white tissue up to 15 cm
  • May be an associated hydrocele or hematocele
Microscopic (histologic) description
  • Dense fibrous tissue, fibroblasts, inflammatory cells, dystrophic calcification
  • With time, cellularity decreases and fibrosis increases
  • Usually no necrosis, no pleomorphism, no / rare mitotic activity (Am J Surg Pathol 2010;34:569)
Microscopic (histologic) images

Images hosted on other servers:

Nodular periorchitis: fibroconnective tissue

Various images

Positive stains
Negative stains
Differential diagnosis