Testis and epididymis
Sex cord stromal tumors
Sclerosing Sertoli cell tumor

Author: Swapnil U. Rane, M.D. (see Authors page)

Revised: 13 June 2017, last major update January 2014

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PubMed Search: Sclerosing sertoli cell tumor of the testis
Cite this page: Sclerosing Sertoli cell tumor. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testissclerosingsertoli.html. Accessed December 11th, 2018.
Definition / general
  • First described by Zukerberg et. al. (Am J Surg Pathol 1991;15:829)
  • Sertoli cell tumor with extensive areas of sclerosis
  • Important to identify because of benign behavior / better prognosis than Sertoli cell tumor NOS and large cell calcifying variant
  • Rare
  • Age range 18 - 80 years (mean age 35 years) (Scand J Urol Nephrol 1999;33:197)
  • No syndromic associations reported (unlike Sertoli cell tumor NOS associated with Peutz-Jegher syndrome or large cell calcifying variant of Sertoli cell tumor associated with Carney complex)
  • Normally descended testis
  • Usually unilateral
  • Occur equally in both testes
Clinical features
  • Usually presents with asymptomatic mass in the testis
  • These tumors are hormonally inactive and gynecomastia is rare (25% of cases of Sertoli cell NOS are associated with gynecomastia)
Radiology description
  • Not specific
  • Well circumscribed hypo - echoic lesion
  • Most patients are treated with high inguinal orchidectomy
  • There is no role of chemotherapy or radiotherapy
  • No recurrence or progression has been reported
Gross description
  • Small (< 2 cm), well circumscribed nodule
  • Cut surface is hard, yellow, white, tan
  • Usually no hemorrhage or necrosis
Microscopic (histologic) description
  • Sertoli cells arranged in well formed tubules, cords or irregular aggregates, separated by extensive hypocellular, collagenous stroma
  • Distinguish from focal sclerosis in Sertoli cell - NOS and large cell calcifying Sertoli cell tumors
Microscopic (histologic) images
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Case of the week #18

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Sclerosing Sertoli cell tumor

Differential diagnosis