Sertoli cell proliferations of infantile testis

Testis and epididymis
Nonneoplastic lesions
Sertoli cell proliferations of infantile testis

Author: Swapnil U. Rane, M.D. (see Authors page)

Revised: 11 April 2017, last major update November 2013

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: sertoli cell tumor infantile testis

Table of Contents

Cite this page: Sertoli cell proliferations of infantile testis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testissertoliinfantile.html. Accessed July 15th, 2017.

Definition / general

Intratubular Sertoli cell proliferations (ISCP) in infantile testis
May actually be discovered later in childhood

Epidemiology

Strongly associated with Peutz-Jeghers syndrome
Occur in normally descended testis

Etiology

Exact cause or molecular event is unknown

Clinical features

Commonly presents as gynecomastia in a young child (N Engl J Med 1991;324:317)
Testicular examination may reveal palpable nodules
May involve both testis simultaneously or sequentially

Radiology description

Ultrasound reveals small, multiple, bilateral hyperechoic images corresponding to numerous foci of ISCP

Prognostic factors

May represent proliferative lesions with neoplastic potential or the intraepithelial stage of some Sertoli cell tumors (Am J Surg Pathol 2001;25:1237), although significance is still unclear
May be associated with large cell calcifying Sertoli cell tumor

Treatment

Traditionally, orchidectomy but no treatment may be recommended for isolated Sertoli cell proliferations

Gross description

Multiple yellowish white nodules on cross section; may be microscopic

Microscopic (histologic) description

Solid cords filled with proliferating Sertoli cells with thickened basement membranes with invaginations
Must exclude Sertoli cell tumor NOS or large cell calcifying Sertoli cell tumor

Immunohistochemistry

Anti-Müllerian hormone (strong), Inhibin α
Thickened basement membrane shows strong PAS+

Definition / general

Large cell calcifying Sertoli cell tumor
- Sertoli cell proliferation beyond the confines of the seminiferous tubules
- Polygonal cells with abundant eosinophilic cytoplasm
- Relatively large nuclei with prominent nucleoli
- Myxoid to fibrous stroma with scattered, large, irregularly shaped islands of calcification