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Testis and epididymis
Germ cell tumors
Spermatocytic seminoma

Reviewer: Rafael Jimenez, M.D. (see Reviewers page)
Revised: 21 April 2013, last major update September 2012
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

Definition
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Epidemiology
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Etiology
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Clinical features
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Prognostic factors
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Case reports
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Treatment
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Gross description
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Gross images
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Mucoid tumor

Nodular gray-white tumor

Cystic and mucoid tumor

Micro description
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Three types of cells:

Micro images
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Diffuse growth pattern

Large nodules have focal
pseudoglandular pattern

Various images


Numerous apoptotic cells

No lymphocytes or granulomas

Edema has caused a cystic pattern

Edema fluid-filled spaces


Figures 1 and 2

Figure 3

Figure 4

Figure 5


Fig 1&2: Polymorphic population of mainly small cells with dark nuclei, intermediate cells with pale nuclei and occasional multinucleated giant cells
Fig 3: Extensive intercellular edema causes a pattern of small nests, trabeculae, clusters and single cells
Fig 4: Intratubular growth: note the filamentous ("spireme") chromatin in some of the larger cells
Fig 5: Intratubular growth: one tubule shows normal spermatogenesis


Unusual features:

Rhabdomyosarcomatous component is desmin+

Tumor nests and cords mixed with lymphocytes

Prominent granulomatous
reaction and
lymphoid infiltrate


Intratubular component surrounded by sarcomatous growth with features of embryonal rhabdomyosarcoma

Sarcomatous component

MAGE-A4+
(also present in spermatogonia)

Cytology description
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Cytology images
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Numerous small lymphocyte-like cells,
intermediate cells with filamentous
chromatin, and rare giant cells

Positive stains
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Negative stains
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Electron microscopy description
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Electron microscopy images
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Figure 1

Figure 2


Fig 1: Intercellular bridge joins two tumor cells, as in normal spermatocytes
Fig 2: A nest of spermatocytic seminoma is surrounded by a well defined basement membrane; there are numerous mitochondria, a Golgi apparatus and round nuclei with dispersed chromatin


Molecular / cytogenetics description
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Differential diagnosis
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End of Testis and epididymis > Germ cell tumors > Spermatocytic seminoma


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