Testis and epididymis
Testicular tumors

Topic Completed: 1 January 2013

Revised: 28 March 2019

Copyright: 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: testicular neoplasms [title] classification

Turki Al-Hussain, M.D.
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Cite this page: Al-Hussain T. Testicular tumors - classification. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testistestclassif.html. Accessed February 27th, 2020.
Modified Armed Forces Institute of Pathology (AFIP) and World Health Organization (WHO) Histologic Classification of Testicular Tumors
Germ Cell Tumors
  • Precursor lesion
    • Intratubular germ cell neoplasm, unclassified
    • Intratubular germ cell neoplasm, specific type
  • Tumors of 1 histologic type
    • Seminoma
      • Variant: Seminoma with syncytiotrophoblastic cells
      • Partially regressed tumor showing seminoma with scar
    • Spermatocytic seminoma
      • Variant: Spermatocytic seminoma with a sarcomatous component
    • Embryonal carcinoma
    • Yolk sac tumor
    • Choriocarcinoma
      • Variant: "Monophasic" type
    • Placental site trophoblastic tumor
    • Trophoblastic tumor, unclassified
    • Teratoma
      • With a secondary somatic type malignant component
      • Monodermal variants
        • Carcinoid
        • Primitive neuroectodermal tumor
        • Others
  • Tumors of more than 1 histologic type
    • Mixed germ cell tumor (specify components; estimate approximate percentage of each)
  • Testicular scar, consistent with regressed tumor
    • Scar only
    • Scar with intratubular germ cell neoplasia
    • Partially regressed tumor with scar and residual germ cell tumor (specify type)

Sex Cord Stromal Tumors
  • Leydig cell tumor
  • Sertoli cell tumor
    • Variant: Large cell calcifying Sertoli cell tumor
    • Variant: Sclerosing Sertoli cell tumor
  • Granulosa cell tumor
    • Adult type
    • Juvenile type
  • Mixed and indeterminate (unclassified) sex cord stromal tumor

Mixed Germ Cell Sex Cord Stromal Tumors
  • Gonadoblastoma
  • Unclassified
Practical Classification
  • Seminoma or nonseminomatous germ cell tumor (NSGCT)
  • Biologically, seminoma and NSGCT are closely linked but treatment is different
  • Rarely, patient has mixed seminoma and NSGCT
Additional references
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