Testis & paratestis
General
WHO classification
Author: Debra L. Zynger, M.D.
Editorial Board Member: Bonnie Choy, M.D.
Deputy Editor-in-Chief: Maria Tretiakova, M.D., Ph.D.
Last author update: 14 February 2023
Last staff update: 14 February 2023
Copyright: 2002-2024, PathologyOutlines.com, Inc.
PubMed Search: Testis tumors WHO classification
Table of Contents
Definition / general | Major updates | WHO (2022) (ICD-O morphology terms if different) | Additional references | Board review style question #1 | Board review style answer #1 | Board review style question #2 | Board review style answer #2Cite this page: Zynger DL. WHO classification. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/testistestclassif.html. Accessed April 25th, 2024.
Definition / general
- WHO classification of tumors of the urinary and male genital organs
- Currently on 5th edition, published in 2022
Major updates
- Germ cell tumors derived from germ cell neoplasia in situ:
- Teratoma with primitive neuroectodermal tumor (PNET) is now called teratoma with embryonic type neuroendocrine differentiation
- Sex cord stromal tumors:
- Signet ring pattern of Sertoli cell tumor is now listed as a separate tumor called signet ring stromal tumor
- Myoid gonadal stromal tumor changed from a provisional entity to a confirmed entity
- Paratesticular mesothelial tumors:
- Well differentiated papillary mesothelioma was renamed well differentiated papillary mesothelial tumor
WHO (2022) (ICD-O morphology terms if different)
Germ cell tumors derived from germ cell neoplasia in situ
Germ cell tumors unrelated to germ cell neoplasia in situ
Sex cord stromal tumors of the testis
Ovarian type tumors of the collecting ducts and rete testis
Tumors of the collecting duct and rete testis
Paratesticular mesothelial tumors
Tumors of the epididymis
Metastatic tumors
- Noninvasive germ cell neoplasia
- Germ cell neoplasia in situ
- Specific forms of intratubular germ cell neoplasia
- Intratubular seminoma
- Intratubular embryonal carcinoma
- Intratubular trophoblast
- Intratubular yolk sac tumor
- Intratubular teratoma
- Gonadoblastoma
- The germinoma family of tumors
- Seminoma
- Seminoma with syncytiotrophoblast cells
- Seminoma
- Nonseminomatous germ cell tumors
- Mixed germ cell tumors
- Mixed germ cell tumors
- Polyembryoma
- Diffuse embryoma
- Mixed germ cell tumors
- Germ cell tumors of unknown type
Germ cell tumors unrelated to germ cell neoplasia in situ
- Spermatocytic tumor
- Spermatocytic tumor with sarcomatous differentiation
- Teratoma, prepubertal type
- Yolk sac tumor, prepubertal type
- Testicular neuroendocrine tumor, prepubertal type (well differentiated neuroendocrine tumor [monodermal teratoma])
- Mixed teratoma and yolk sac tumor, prepubertal type
Sex cord stromal tumors of the testis
- Leydig cell tumor
- Sertoli cell tumor (Sertoli cell tumors)
- Granulosa cell tumors
- Tumors in the fibroma thecoma group (the fibroma thecoma family of tumors)
- Thecoma
- Fibroma
- Mixed and other sex cord stromal tumors
- Mixed sex cord stromal tumor
- Signet ring stromal tumor
- Myoid gonadal stromal tumor
- Sex cord stromal tumor, NOS
Ovarian type tumors of the collecting ducts and rete testis
- Serous cystadenoma (serous cystadenoma, NOS)
- Serous tumor of borderline malignancy (serous borderline tumor, NOS)
- Serous cystadenocarcinoma
- Mucinous cystadenoma
- Mucinous borderline tumor
- Mucinous cystadenocarcinoma
- Endometrioid tumor, borderline
- Endometrioid adenocarcinoma
- Clear cell adenocarcinoma
- Brenner tumor
Tumors of the collecting duct and rete testis
- Adenoma of the collecting ducts and rete testis (adenoma)
- Adenocarcinoma of the collecting ducts and rete testis (adenocarcinoma)
Paratesticular mesothelial tumors
Tumors of the epididymis
- Cystadenoma of the epididymis
- Papillary cystadenoma of the epididymis (papillary cystadenoma)
- Adenocarcinoma of the epididymis
- Squamous cell carcinoma of the epididymis (squamous cell carcinoma)
- Melanotic neuroectodermal tumor of the epididymis (melanotic neuroectodermal tumor)
Metastatic tumors
Additional references
Board review style question #1
Spermatocytic tumor, shown in the image above, is an example of which of the following categories of testicular tumors?
- Germ cell tumors derived from germ cell neoplasia in situ
- Germ cell tumors unrelated to germ cell neoplasia in situ
- Sex cord stromal tumors
- Tumor containing both germ cell and sex cord stromal elements
Board review style answer #1
B. Germ cell tumors unrelated to germ cell neoplasia in situ. Spermatocytic tumor is a germ cell tumor that is not derived from germ cell neoplasia in situ. Most germ cell tumors such as seminoma are thought to be derived from the precursor lesion germ cell neoplasia in situ. Spermatocytic tumor is not a sex cord stromal tumor and does not have sex cord stromal elements.
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Reference: Testis & paratestis - WHO classification
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Reference: Testis & paratestis - WHO classification
Board review style question #2
Seminoma, shown in the image above, is an example of which of the following categories of testicular tumors?
- Germ cell tumors derived from germ cell neoplasia in situ
- Germ cell tumors unrelated to germ cell neoplasia in situ
- Sex cord stromal tumors
- Tumor containing both germ cell and sex cord stromal elements
Board review style answer #2
A. Germ cell tumors derived from germ cell neoplasia in situ. Seminoma is thought to be derived from the precursor lesion germ cell neoplasia in situ. It is not a sex cord stromal tumor and does not contain sex cord stromal elements.
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Reference: Testis & paratestis - WHO classification
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Reference: Testis & paratestis - WHO classification
