Testis & epididymis
General
World Health Organization (WHO) 2016 classification of tumors of the testis and paratesticular tissue

Editorial Board Member: Maria Tretiakova, M.D., Ph.D.
Debra Zynger, M.D.

Topic Completed: 21 April 2020

Minor changes: 21 April 2020

Copyright: 2002-2020, PathologyOutlines.com, Inc.

PubMed Search: Testis tumors WHO classification[TIAB]

Debra Zynger, M.D.
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Cite this page: Zynger D. World Health Organization (WHO) 2016 classification of tumors of the testis and paratesticular tissue. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testistestclassif.html. Accessed June 1st, 2020.
WHO (2016)
Germ cell tumors derived from germ cell neoplasia in situ
  • Noninvasive germ cell neoplasia
    • Germ cell neoplasia in situ
    • Specific forms of intratubular germ cell neoplasia
  • Tumors of a single histological type (pure forms)
    • Seminoma
    • Seminoma with syncytiotrophoblast cells
  • Nonseminomatous germ cell tumors
    • Embryonal carcinoma
    • Yolk sac tumor, postpubertal type
    • Trophoblastic tumors
      • Choriocarcinoma
      • Nonchoriocarcinomatous trophoblastic tumors
      • Placental site trophoblastic tumor
      • Epithelioid trophoblastic tumor
      • Cystic trophoblastic tumor
    • Teratoma, postpubertal type
    • Teratoma with somatic type malignancy
  • Nonseminomatous germ cell tumors of more than one histological type
    • Mixed germ cell tumors
  • Germ cell tumors of unknown type
    • Regressed germ cell tumors

Germ cell tumors unrelated to germ cell neoplasia in situ
  • Spermatocytic tumor
  • Teratoma, prepubertal type
    • Dermoid cyst
    • Epidermoid cyst
    • Well differentiated neuroendocrine tumor (monodermal teratoma)
  • Mixed teratoma and yolk sac tumor, prepubertal type
  • Yolk sac tumor, prepubertal type

Sex cord stromal tumors
  • Pure tumors
    • Leydig cell tumor
      • Malignant Leydig cell tumor
    • Sertoli cell tumor, NOS
      • Malignant Sertoli cell tumor
      • Large cell calcifying Sertoli cell tumor
      • Intratubular large cell hyalinizing Sertoli cell neoplasia
    • Granulosa cell tumor
      • Adult granulosa cell tumor
      • Juvenile granulosa cell tumor
    • Tumors in the fibroma thecoma group
  • Mixed and unclassified sex cord stromal tumors
    • Mixed sex cord stromal tumor
    • Unclassified sex cord stromal tumor

Tumor containing both germ cell and sex cord stromal elements
  • Gonadoblastoma

Miscellaneous tumors of the testis
  • Ovarian epithelial type tumors
    • Serous cystadenoma
    • Serous tumor of borderline malignancy
    • Serous cystadenocarcinoma
    • Mucinous cystadenoma
    • Mucinous borderline tumor
    • Mucinous cystadenocarcinoma
    • Endometrioid adenocarcinoma
    • Clear cell adenocarcinoma
    • Brenner tumor
  • Juvenile xanthogranuloma
  • Hemangioma

Hematolymphoid tumors
  • Diffuse large B cell lymphoma
  • Follicular lymphoma, NOS
  • Extranodal NK / T cell lymphoma, nasal type
  • Plasmacytoma
  • Myeloid sarcoma
  • Rosai-Dorfman disease

Tumors of collecting duct and rete testis
  • Adenoma
  • Adenocarcinoma

Tumors of paratesticular structures
  • Adenomatoid tumor
  • Mesothelioma
    • Well differentiated papillary mesothelioma
  • Epididymal tumors
    • Cystadenoma of the epididymis
    • Papillary cystadenoma
    • Adenocarcinoma of the epididymis
  • Squamous cell carcinoma
  • Melanotic neuroectodermal tumor
  • Nephroblastoma
  • Paraganglioma

Mesenchymal tumors of the spermatic cord and testicular adnexa
  • Adipocytic tumors
    • Lipoma
    • Well differentiated liposarcoma
    • Dedifferentiated liposarcoma
    • Myxoid liposarcoma
    • Pleomorphic liposarcoma
  • Smooth muscle tumors
    • Leiomyoma
    • Leiomyosarcoma
  • Skeletal muscle tumors
    • Rhabdomyoma
    • Rhabdomyosarcoma
      • Embryonal type
      • Alveolar type
      • Pleomorphic type
      • Spindle cell / sclerosing type
  • Fibroblastic / myofibroblastic tumors
    • Cellular angiofibroma
    • Mammary type myofibroblastoma
    • Deep ("aggressive") angiomyxoma
  • Nerve sheath tumors
  • Other mesenchymal tumors of the spermatic cord and testicular adnexa
    • Hemangioma
    • Desmoplastic round cell tumor

Metastatic tumors
Board review style question #1



Spermatocytic tumor, shown in the image, is an example of which of the following categories of testicular tumors?

  1. Germ cell tumors derived from germ cell neoplasia in situ
  2. Germ cell tumors unrelated to germ cell neoplasia in situ
  3. Sex cord stromal tumors
  4. Tumor containing both germ cell and sex cord stromal elements
Board review answer #1
Board review style question #2



Seminoma, shown in the image, is an example of which of the following categories of testicular tumors?

  1. Germ cell tumors derived from germ cell neoplasia in situ
  2. Germ cell tumors unrelated to germ cell neoplasia in situ
  3. Sex cord stromal tumors
  4. Tumor containing both germ cell and sex cord stromal elements
Board review answer #2
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