Testis & epididymis

Topic Completed: 1 August 2012

Minor changes: 9 September 2020

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PubMed Search: Testotoxicosis

Turki Al-Hussain, M.D.
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Cite this page: Al-Hussain T. Testotoxicosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/testistestotox.html. Accessed November 27th, 2020.
Definition / general
  • Form of male sexual precocity with active Leydig cell differentiation and premature onset of spermatogenesis without pituitary gonadotropin stimulation (Arch Pathol Lab Med 1985;109:990)
  • Due to apparent inherited intratesticular defect
Microscopic (histologic) description
  • Leydig cells appear fully differentiated
  • No Reinke crystals
  • Germ cells at all stages of spermatogenesis present but with disordered maturation
  • Structural abnormalities in spermatids
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