Thyroid gland
Other malignancies
Angiosarcoma

Author: Sheren Younes, M.D. (see Authors page)

Revised: 17 February 2017, last major update August 2015

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: angiosarcoma thyroid

Cite this page: Angiosarcoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/thyroidangiosarcoma.html. Accessed April 30th, 2017.
Definition / general
  • Seen in elderly in Alpine regions of Europe, where tumor may comprise 16% of thyroid malignancies, due to high prevalence of iodine deficient goiter
  • Non-Alpine tumors are rare
Clinical features
  • Thyroid mass
  • Compression symptoms
  • Symptoms related to distant metastasis
Prognostic factors
Case reports
Gross description
  • Single nodule commonly filled with bloody fluid, compressing thyroid
Gross images

Images hosted on PathOut server:

Necrotic and hemorrhagic tumor (AFIP)



Images hosted on other servers:

Thyroid gland with tumor at autopsy

Microscopic (histologic) description
  • Pleomorphic tumor, usually poorly differentiated, with irregular slit vascular spaces with anastomosing channels or discrete cytoplasmic vacuoles
  • Epithelioid variant has poorly circumscribed growth in sheets / cords, intracytoplasmic lumina filled with RBCs; composed of polygonal epithelioid cells with abundant eosinophilic cytoplasm, vesicular nuclei, prominent amphophilic-basophilic nucleoli
Microscopic (histologic) images

Images hosted on PathOut server:

Solid and cellular areas

Abortive vascular lumina

Keratin+ tumor cells

Vimentin+


Plump endothelial, Factor VIII+

Ulex europaeus I lectin+

Type IV collagen stains basal lamina



Images hosted on other servers:

Epithelioid tumor

CD31+, AE1 / AE3, Factor VIII

Cytology description
  • Cellular smear with single cells and small clusters of oval and round tumor cells
  • Cell borders are indistinct and cytoplasm is vacuolated
  • Nuclei are eccentric with coarse chromatin, irregular membranes and a single, prominent nucleoli
  • Also features suggestive of intracytoplasmic lumens (Acta Cytol 2002;46:767)
Positive stains
Negative stains
Differential diagnosis