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Thyroid gland
Hyperplasia / goiter
C cell hyperplasia (CCH)

Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 7 June 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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Two types (although literature does not always specify):
Epidemiology
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Clinical features
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Case reports
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Treatment
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Gross description
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Micro description
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Methodology:
Reactive CCH criteria:
Neoplastic CCH criteria:
Patterns of CCH are:
Micro images
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Sporadic neoplastic CCH
Nodular and non-nodular forms
High power
Associated with nodular goiter
MEN2A patient
Contributed by Dr. Mark R. Wick

MEN 2A patients (AFIP):
Circumferential proliferation of C cells around follicular cells
Focal proliferation of C cells (arrow)
C cells form an eccentric intrafollicular proliferation

MEN 2A patients with early medullary carcinoma (AFIP):
Group of C cells extends into interstitium

Calcitonin staining:
C cells highlighted (AFIP)
C cells form ring around follicle
Sporadic focal CCH
Sporadic diffuse CCH
Pseudonodular CCH
Sporadic diffuse and nodular CCH
Nodular CCH
Nodular CCH (fig b/c)

CCH (? neoplastic) in
patient with familial
medullary carcinoma
C cells adjacent to follicular carcinoma (AFIP)
Radiation induced CCH
Contributed by Dr. Mark R. Wick
Cytology description
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Positive stains
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Negative stains
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Electron microscopy description
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Electron microscopy images
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MEN2A patient
Molecular / cytogenetics description
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Differential diagnosis
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End of Thyroid gland > Hyperplasia / goiter > C cell hyperplasia (CCH)


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