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Thyroid gland
Miscellaneous
Clear cell change

Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 13 June 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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Case reports
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Gross images
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Nodular hyperplasia with clear cell change (AFIP)

Micro images
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Hashimoto's thyroiditis with clear cells
Nodular hyperplasia
Papillary carcinoma:
Clear cell change
Clear cell change (follicular variant)

Follicular neoplasms:
Follicular carcinoma
Follicular neoplasm with clear cell change
Signet ring follicular adenoma
Oncocytic neoplasms:
Sharp demarcation between clear and oncocytic cells
Gradual transition from oncocytic to clear cells
Both patterns exist in same cell
Renal cell carcinoma metastases:
Clear cell type
Stains:
Signet ring follicular adenoma is thyroglobulin+

Cytology description
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Stains
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Electron microscopy images (AFIP)
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Marked dilation of cisternae of granular endoplasmic reticulum
Signet ring follicular adenoma
Differential diagnosis
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End of Thyroid gland > Miscellaneous > Clear cell change


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