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Nodular Goiter

Medical Knowledge
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Practice Based Learning
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Cytology images
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Watery colloid

Watery colloid and focal dense colloid

Large amounts of background colloid

Thick, deep blue colloid with cracking

Thick, deep blue colloid with bubble pattern


Sheet of benign follicular epithelial cells

Fig 18-4a: benign epithelial cells, colloid, macrophages

Thin Prep versus pap stain



Hyperplastic/Adenomatoid nodule

Medical Knowledge
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Practice Based Learning
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Cytology images
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Pediatric Solitary Papillary Hyperplastic Thyroid Nodule



Chronic lymphocytic thyroiditis

Medical Knowledge
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Practice Based Learning
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Cytology images
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Lymphoid and follicular epithelial cells

Oncocytic cells with atypical nuclei

Sheet of follicular cells with oncocytic change mixed with benign lymphoid cells (third image also has giant cells)


Resembles lymphoma

Grade I: mild lymphocytic inflammatory infiltrate

Grade II: moderate lymphocytic inflammation

Grade III - marked inflammation with polymorphous lymphocytes

Thin Prep versus pap stain



Other inflammatory conditions of the thyroid

Medical Knowledge
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Practice Based Learning
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Cytology images
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Subacute thyroiditis

Syncytial cluster of epithelioid cells with oval nuclei

Large multi-nucleated giant cell

Multinucleated giant cells in case associated with renal cell carcinoma

Multinucleated giant cells and individual epithelial cells

Epithelioid cells and lymphocytes

End of Thyroid > Competency Assessment > Benign thyroid lesions



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