Hypothyroidism - cretinism
Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 1 April 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Congenital hypothyroidism, now rare due to newborn testing and iodine supplementation
although incidence at screening has been increasing in US
(Mol Genet Metab 2007;91:268)
- Symptoms include impaired development of skeletal system (short, coarse facial features and protruding tongue), severe mental retardation, increased risk of GU abnormalities
(J Pediatr 2009;154:263)
- Maternal hypothyroidism may cause severe mental retardation, because maternal T3 / T4 crosses placenta and is critical to fetal brain development before fetal thyroid gland develops
- Usually due to thyroid dysgenesis / agenesis, rarely due to inborn errors of metabolism
End of Thyroid gland > Endocrine abnormalities > Hypothyroidism - cretinism
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