Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 31 March 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Intracellular deposits of cysteine, but must fix tissue in absolute alcohol, not formalin, or crystals will dissolve
- Follicular atrophy with fibrosis and decreased colloid
- Focal papillary hyperplasia with dilated follicles and focal neutrophils
Figure 1: bone marrow (not thyroid) macrophages contain clusters of hexagonal, tubular, and rectangular cysteine crystals, which are birefringent using polarizing (fig 2) and first-order compensator filters (fig 3)
Macrophage with cysteine crystals
End of Thyroid gland > Congenital anomalies > Cystinosis
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