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Thyroid gland
Papillary carcinoma
Diffuse sclerosing variant

Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 12 June 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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Epidemiology
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Laboratory
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Prognostic factors
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Case reports
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Gross images
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Both thyroid lobes show diffuse growth and fibrosis (AFIP)
Fibrotic cut surface
Micro description
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Micro images
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Extensive stromal sclerosis around small island of tumor cells, many psammoma bodies
(Fig. 1D) Scattered psammoma bodies
Left - papillary carcinoma, right - fibrosis, psammoma bodies and inflammation
Dense sclerosis, squamous metaplasia and a lymphocytic infiltrate

Fig 1: nodular thyroid (inset is cut surface)
Fig 2: solid nests of tumor cells
Fig 3: irregular nuclear contours, nuclear clefts,
occasional nuclear pseudoinclusions
Fig 4: tumor nests within lymphatics
Diffuse infiltration
Chronic inflammatory infiltrate
Sclerosis, squamous metaplasia and lymphatic invasion
Images from AFIP:
Dense fibrosis
Tumor grows within endothelial lined spaces
Tumor cells are within endothelial lined space
Solid growth pattern with lymphocytic inflammation
Marked fibrosclerotic changes
Cytology description
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Cytology images
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Metaplastic squamous cells with scattered lymphocytes
(Fig. 1C) Scattered follicular cell clusters
Positive stains
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Molecular / cytogenetics description
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Differential diagnosis
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End of Thyroid gland > Papillary carcinoma > Diffuse sclerosing variant


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