Thyroid gland
Focal lymphocytic thyroiditis

Author: Shahidul Islam, M.D., Ph.D. (see Authors page)

Revised: 12 January 2017, last major update March 2009

Copyright: (c) 2003-2017,, Inc.

PubMed Search: focal lymphocytic thyroiditis
Cite this page: Focal lymphocytic thyroiditis. website. Accessed June 21st, 2018.
Definition / general
  • Focal lymphocytes in thyroid gland
  • Usually an incidental finding
Clinical features
  • Associated with low levels of antithyroid antibodies, lack of clinical symptoms
  • May be early or mild form of autoimmune thyroiditis (J Clin Pathol 1969;22:326)
  • None
Gross description
  • No findings
Microscopic (histologic) description
  • Focal aggregates of lymphocytes in inter- or intralobular fibrous tissue
  • No oxyphilic metaplasia, no follicular atrophy, no follicular disruption
  • May be associated with other thyroid disease
Microscopic (histologic) images

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Patchy lymphocytic inflammation

Small lymphocytes,
occasional plasma cells
and large lymphocytes

Electron microscopy description
Electron microscopy images

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Chromatin is coarsely condensed at nuclear periphery,
cytoplasm contains abundant single, free ribosomes,
a single endoplasmic reticulum and small mitochondria