Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Thyroid gland
Benign neoplasms
Follicular adenoma

Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 14 June 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
=========================================================================
Terminology
=========================================================================
Diagnosis
=========================================================================
Case reports
=========================================================================
Treatment
=========================================================================
Gross description
=========================================================================
Gross images
=========================================================================
Well circumscribed tumor
Thin capsule
Well encapsulated
Central scar
Cystic and partially necrotic tumor
Contributed by Dr. Mark R. Wick
Images from AFIP:
Encapsulated, homogeneous tan cut surface
Bisected adenoma has fresh hemorrhage
Marked necrosis, hemorrhage and cystic change
Marked cystic degeneration
Micro description
=========================================================================
Micro images
=========================================================================

Images from AFIP:
Thin and uniform fibrous capsule
Marked fibrosis and stromal hyalinization
Marked hyaline thickening of vessel walls
Marked fibrosis, hyalinization and calcium deposition
Marked vascularization resembles a vascular neoplasm
Capsular vessel with smooth muscle cells
Bizarre nuclei
Large, extremely irregular nuclei
With papillary hyperplasia
With papillary hyperplasia and adipose metaplasia
Cartilaginous metaplasia (adenochondroma)
Toxic adenoma is solitary and unencapsulated
Prominent clear cell change
Squamous metaplasia
Mucin production
Other images:
Trabecular type
Bizarre nuclei
Clear cell adenoma
Adjacent atrophic follicular epithelium
Patterns:
Macrofollicular
Microfollicular with sharp circumscription by delicate fibrous capsule
Microfollicular
Microfollicular
Microfollicles have regular nuclei and interfollicular edema
Encapsulated microfollicular adenoma
Microfollicular, trabecular and solid
Insular
Spindle cell type
Patterns from AFIP:
A: solid, B: trabecular, C: microfollicular, D: macrofollicular
Left: macrofollicular, right: solid pattern
Signet ring
Atypical adenomas (AFIP)
Markedly cellular with irregular growth
Well formed follicles merge with solid pattern
Spindle cells mix with round cells
Not invasion:

Fine needle induced changes resemble invasion (AFIP)
Stains:
Signet ring follicular adenoma is thyroglobulin+ (AFIP)
Signet ring pattern, Alcian blue+
H&E, HBME1, CK19
Contributed by Dr. Mark R. Wick:
Cellular follicular adenoma
Virtual slides
=========================================================================
Microfollicular pattern
Toxic adenoma
Cytology description
=========================================================================
Cytology images
=========================================================================
Microfollicular
Microfollicular
Macrofollicular
FNA and H&E
Round hyperchromatic nuclei
Positive stains
=========================================================================
Negative stains
=========================================================================
Electron microscopy images
=========================================================================

Images from AFIP:
Abundant dilated endoplasmic reticulum
Microvilli project into well developed lumina
Signet ring follicular adenoma
Molecular / cytogenetics description
=========================================================================
Videos
=========================================================================



Histopathology Thyroid --Follicular adenoma (microfollicular)
by John R. Minarcik, M.D.

Differential diagnosis
=========================================================================
End of Thyroid gland > Benign neoplasms > Follicular adenoma


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).