Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Thyroid gland
Papillary carcinoma
Follicular variant

Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 12 June 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

See also diffuse follicular variant or encapsulated follicular variant

General
=========================================================================
Diagnosis
=========================================================================
Prognostic factors
=========================================================================
Case reports
=========================================================================
Micro description
=========================================================================
Micro images
=========================================================================
Follicular epithelial cells have ground glass nuclei and occasional nuclear grooves
Vesicular nuclei and hemorrhage in follicular lumina
Crowded nuclei and scalloped colloid
H&E, HBME1, CK19
H&E, HBME and galectin-3
Contributed by Dr. Mark R. Wick
Images from AFIP:
Wide fibrous bands
Microfollicular and macrofollicular patterns
Macrofollicular formations resemble nodular hyperplasia
Clear cytoplasm
Nuclei are overlapping with empty appearance
Some neoplastic follicles lined by granular acidophilic cells
Clear cell change
Intraluminal colloid
Combined with other tumors:
Follicular pattern of papillary carcinoma at bottom (AFIP)
Various images (AFIP)
Collision tumor with squamous cell carcinoma
Virtual slides
=========================================================================
Childhood tumor, metastatic to lung
Van Gieson
Cytology description
=========================================================================
Cytology images
=========================================================================
Cellular aspirates with some microfollicular aggregates, no colloid
Nuclear features are prominent with scrape cytology
Acinar arrangement with intranuclear inclusion
Figure 1
Figure 2
Figure 3
Fig 1: Ovoid and pear-shaped hypochromatic nuclei and nuclear grooves; cells show nuclear overlap, round / oval hypochromatic nuclei, eccentric small nucleoli, and nuclear grooves (arrow)
Fig 2: Cells have powdery chromatin, nuclear grooves and intranuclear cytoplasmic inclusions
Fig 3: Enlarged round / oval nuclei, but papillary nuclear features are difficult to appreciate

Positive stains
=========================================================================
Molecular / cytogenetics description
=========================================================================
Differential diagnosis
=========================================================================
Additional references
=========================================================================
End of Thyroid gland > Papillary carcinoma > Follicular variant


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).