Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Thyroid gland
Other thyroid carcinoma
Hürthle cell (oncocytic) tumors

Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 13 June 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

See also minimally invasive Hürthle cell carcinoma below

Note: this section includes benign and malignant tumors

General
=========================================================================
Epidemiology
=========================================================================
Prognostic factors
=========================================================================
Case reports
=========================================================================
Treatment
=========================================================================
Gross description
=========================================================================
Gross images
=========================================================================

Images from AFIP:
Adenoma with massive infarct
Carcinoma has focal capsular invasion
Carcinoma, contributed by Dr. Mark R. Wick
Micro description
=========================================================================
Micro images
=========================================================================

Adenoma:
Hürthle cell adenoma, contributed by Grace C. H. Yang, M.D.
Psammoma bodies in Hurthle cell neoplasm (figure 3)
Adenoma with atypia, contributed by Dr. Mark R. Wick

Adenoma - AFIP:
Oncocytic adenoma has follicular pattern
Cytoplasm has fine, homogeneously distributed granularity
Massive infarct due to fine needle biopsy
Pseudo-angiosarcomatous pattern
Well developed papillary growth pattern
Psammoma bodies in follicular lumina
Tumor has hyalinized area near capsule
Tumor has focal cells with large hyperchromatic nuclei
Focal papillary formations
Clear cell change - AFIP:
Sharp demarcation between clear and oncocytic cells
Gradual transition from oncocytic to clear cells
Both patterns exist in same cell
Carcinoma - AFIP:
Capsular invasion
Vascular invasion
Trabecular pattern
Multinodular pattern
Nesting pattern resembles insular carcinoma
Pseudopapillary formations due to tangential sectioning
Pulmonary metastasis of tumor with trabecular growth pattern
Carcinoma - other sources:
Capsular invasion
Vascular invasion (fig B)
Oncocytes with abundant eosinophilic granular cytoplasm
Carcinoma images contributed by Dr. Mark R. Wick
Oncocytes with abundant eosinophilic granular cytoplasm with intraluminal calcifications
No capsular invasion evident
Tumor in internal jugular vein
Various images
Microfollicles
Cells have eosinophilic cytoplasm and prominent nucleoli
Metastasis to breast
Ki-67 and cyclin D1
Mixed oncocytic and mucinous secreting carcinoma
Ki-67- mucus secreting carcinoma
p53 - mucus secreting carcinoma
Cytology description
=========================================================================
Cytology images
=========================================================================
Various images
Microfollicles of carcinoma
Hürthle cell adenoma, 10x Diff-Quik
Hürthle cell adenoma, 2x pap stain
Hürthle cell adenoma, 10x pap stain
Positive stains
=========================================================================
Electron microscopy description
=========================================================================
Electron microscopy images
=========================================================================
Cytoplasm is packed with mitochondria
Cytoplasm packed with large mitochondria with myelin figures (AFIP)
Dilated mitochondria have reduced cristae (AFIP)
Carcinoma, contributed by Dr. Mark R. Wick
Molecular / cytogenetics description
=========================================================================
Differential diagnosis
=========================================================================
Additional references
=========================================================================


Minimally invasive Hürthle cell carcinoma
General
=========================================================================
Terminology
=========================================================================
Micro images
=========================================================================
Intracapsular vascular invasion
Vascular invasion
Distant metastasis to femur
Fine needle biopsy induced necrosis (AFIP)
End of Thyroid gland > Other thyroid carcinoma > Hürthle cell (oncocytic) tumors


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).