Thyroid gland
Lithium thyroiditis

Author: Shahidul Islam, M.D., Ph.D. (see Authors page)

Revised: 12 January 2017, last major update March 2009

Copyright: (c) 2003-2017,, Inc.

PubMed Search: lithium thyroiditis
Cite this page: Lithium thyroiditis. website. Accessed December 17th, 2018.
Definition / general
  • Lithium directly damages thyroid follicular cells, which releases thyroglobulin, which may be hydrolyzed to thyroxine, causing hyperthyroidism
Case reports
Microscopic (histologic) description
  • Small follicles with atrophy and minimal colloid; follicles contain desquamated follicular cells, macrophages and multinucleated giant cells; some giant cells contain birefringent calcium oxalate crystals (J Clin Pathol 1995;48:582)
Microscopic (histologic) images

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Case of the Week #139

Differential diagnosis