Thyroid gland
Thyroiditis
Lithium thyroiditis




Topic Completed: 1 March 2009

Revised: 15 March 2019

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Cite this page: Islam S. Lithium thyroiditis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/thyroidlithiumthyroiditis.html. Accessed May 23rd, 2019.
Definition / general
  • Lithium directly damages thyroid follicular cells, which releases thyroglobulin, which may be hydrolyzed to thyroxine, causing hyperthyroidism
Case reports
Microscopic (histologic) description
  • Small follicles with atrophy and minimal colloid; follicles contain desquamated follicular cells, macrophages and multinucleated giant cells; some giant cells contain birefringent calcium oxalate crystals (J Clin Pathol 1995;48:582)
Microscopic (histologic) images

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Case of the Week #139

Differential diagnosis
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