Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 4 April 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Macrofollicles (large dilated follicles) > 50% of cross sectional area, with papillary nuclear features
- Very rare; similar clinical features as classic papillary carcinoma (female predominant, occasional nodal metastases, few deaths)
- May have minor (< 5%) insular component that does not appear to affect prognosis
- Mean 3 cm, often encapsulated
- Frequent macrofollicles (> 50% of cross sectional area) and foci of follicular variant of papillary carcinoma, all with prominent, large ground-glass nuclei and nuclear grooves
(Hum Pathol 1991;22:1195)
- Also cells with large but less pale nuclei with stippled chromatin, or cuboidal cells with hyperchromatic nuclei
Various images (figures 1-3, 6)
End of Thyroid gland > Papillary carcinoma > Macrofollicular variant
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