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General
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Terminology
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Epidemiology
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Papillary thyroid carcinoma
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Follicular Carcinoma
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Medullary thyroid carcinoma
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Poorly Differentiated Thyroid Carcinoma
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Undifferentiated (Anaplastic) Carcinoma
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Squamous Cell Carcinoma of Thyroid
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Metastatic tumors
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Non-Hodgkin Lymphoma
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Treatment
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Cytology images
Papillary thyroid carcinoma

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Various images

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Nuclear grooves

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Grooves and nucleoli

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Intranuclear cytoplasmic invaginations

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Grooves and pseudoinclusions

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Intranuclear pseudoinclusions

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Cellular crowding

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Branching papillae

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Nuclear crowding

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Monolayered sheet

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Intact papilla

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Large papillary fragment

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Dense, 'squamoid' looking cytoplasm

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Monolayered, follicular aspect of group at top

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Cohesive fragments of follicular epithelium

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Flat monolayered sheet of follicular epithelium

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Fine chromatin distribution

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Thick globoid colloid

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Oval to elongated nuclear shapes

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Powdery, "ground glass" chromatin

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Finely dispersed uniform chromatin

Poorly Differentiated Carcinoma
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Isolated malignant cells

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Malignant cells and clusters

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Overlapping cells with granular chromatin

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Acinar or microfollicular arrays

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Crowded, hyperchromatic follicular epithelial cells

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Nuclei have irregular outlines

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Insular carcinoma

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Crowded group of epithelial cells

Medullary Thyroid Carcinoma
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Spindle-shaped cells

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Epithelioid and spindle-shaped cells

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Spindle-shaped and plasmacytoid cells

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Isolated plasmacytoid cells with karyomegaly

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Dyscohesive elongated and 'plasmacytoid' cells

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'Plasmacytoid' cells with 'salt and pepper' chromatin

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Discohesive "plasmacytoid" cells

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Epithelioid and fusiform

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Amyloid surrounded by fusiform cells

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Monomorphic fusiform cells

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Epithelioid cells with anisonucleosis

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Large epithelioid cells

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Coarsely granular chromatin

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Discohesive tumor cells

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Few cells show cytoplasmic granularity

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Few discohesive tumor cells

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Typical appearance of neuroendocrine granules

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Loosely cohesive, monotonous malignant cells

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Monomorphic round nuclei

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Tight grouping of malignant cells

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Congo red

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Calcitonin

Undifferentiated (anaplastic) Carcinoma
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Anaplastic Carcinoma of Thyroid

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Pap stained

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Extreme pleomorphism

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Malignant cells admixed with macrophages

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Rhabdoid appearance

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Spindle cells

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Poorly preserved inflammatory cells

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Irregular nuclei with prominent nucleoli

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A crowded group of atypical spindle cells

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Fragment of malignant pleomorphic cells

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Epithelioid appearance

Metastatic Carcinoma
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Colon Carcinoma
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Esophageal Adenocarcinoma
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Gastric Carcinoma - Signet Ring
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MALT (metastatic)
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Merkel Cell
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Renal Cell Carcinoma
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Non-Hodgkin Lymphoma:
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Lymphoid population devoid of epithelial cells

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Large atypical lymphocytes

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Hypercellular smear

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Numerous lymphoglandular bodies

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Diffuse large B cell lymphoma

Other
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Squamous Cell Carcinoma of the Thyroid
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Keratinizing malignant cells



Mucoepidermoid Carcinoma of the Thyroid
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Squamous differentiation

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Prominent nucleoli

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Intermediate-type cells

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Small pearl

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Intermediate-type cells

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Glandular-type cells

Immunohistochemistry
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Molecular / cytogenetics description
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Differential diagnosis
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Additional references
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End of Thyroid > Bethesda guidelines for Cytology > Malignant



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