Thyroid gland
Other malignancies

Author: Sheren Younes, M.D. (see Authors page)

Revised: 20 February 2017, last major update December 2014

Copyright: (c) 2014-2017,, Inc.

PubMed Search: neuroblastoma thyroid

Cite this page: Neuroblastoma. website. Accessed May 21st, 2018.
Definition / general
  • Childhood tumor, primarily arising in sites with sympathetic neural tissue
  • Very rare in thyroid
  • See also Adrenal gland topic
Clinical features
  • Thyroid mass
Case reports
Gross description
  • Well circumscribed, soft, grayish tan, cut section shows hemorrhage and necrosis
Microscopic (histologic) description
  • Cellular tumor
  • Small cells arranged in aggregates or rosettes with central cellular debris
  • Homer-Wright rosettes, separated by delicate fibrovascular cores
  • Cells are small, monomorphic, hyperchromatic with indistinct cytoplasm and nucleoli
  • Neurofibrillary background
Microscopic (histologic) images

Images hosted on other servers:

Various images

Cytology description
  • Cellular
  • Arranged in sheets or forming rosettes
  • Cells are small, with hyperchromatic nuclei, indistinct nucleoli
  • Indistinguishable cytoplasm
  • There may be neurofilamentous material in the background
Negative stains
Electron microscopy description
  • Undifferentiated small cells
Differential diagnosis