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Thyroid gland
Hyperplasia / goiter
Simple goiter and nontoxic multinodular goiter

Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 10 June 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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Terminology
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Epidemiology
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Etiology
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Causes of simple goiter or nontoxic multinodular goiter:
Clinical features
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Laboratory
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Radiology images
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Intramediastinal - Contributed by Dr. Mark R. Wick
Case reports
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Treatment
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Gross description
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Gross images
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Colloid goiter
Nodular goiter
Retrosternal goiter
Contributed by Dr. Mark R. Wick
Images from AFIP:
Various sized nodules
Nodular hyperplasia
Numerous poorly circumscribed nodules
Clear cell change microscopically
Micro description
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Micro images
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Irregularly enlarged follicles with flattened epithelium
Colloid goiter
Colloid goiter with cholesterol clefts
Squamous metaplasia (CK 5/6+) in capsule
Images from AFIP:
No capsule identified
Sanderson’s polster
With hypercellular focus
With adipose metaplasia of stroma
Papillary area
Clear cell change
With focal squamous metaplasia
Images contributed by Dr. Mark R. Wick:
Pseudopapillary
Colloid, PAS stain
Virtual slides
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Nodular goiter
Cytology description
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Cytology images
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Watery colloid and focal dense colloid
Large amounts of background colloid
Videos
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"Histopathology Thyroid--Nodular goiter"
by John R. Minarcik, M.D.


"Histopathology Thyroid--Colloid goiter"
by John R. Minarcik, M.D.

Differential diagnosis
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End of Thyroid gland > Hyperplasia / goiter > Simple goiter and nontoxic multinodular goiter


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