Thyroid gland
Papillary carcinoma
Papillary carcinoma in children



Topic Completed: 1 March 2009

Revised: 26 April 2019

Copyright: 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: pediatric papillary thyroid carcinoma

Shahid Islam, M.D., Ph.D.
Page views in 2018: 162
Page views in 2019 to date: 127
Cite this page: Islam S. Papillary carcinoma in children. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/thyroidptdchildren.html. Accessed July 17th, 2019.
Definition / general
  • Children present with more advanced disease than adults, but have better prognosis (Hormones (Athens) 2007;6:200, eMedicine)
  • Regional nodal metastases occur in 60 - 80%, distant metastases in 10 - 20% at diagnosis, often lung
  • Risk factors: family history, prior radiation exposure
Prognostic factors
Case reports
Molecular / cytogenetics description
  • RET rearrangements more common than adults, BRAF activation less common (20% versus 77% in adults, Mod Pathol 2005;18:898)
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