Papillary carcinoma in children
Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 4 April 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.
- Children present with more advanced disease than adults, but have better prognosis
(Hormones (Athens) 2007;6:200, eMedicine)
- Regional nodal metastases occur in 60-80%, distant metastases in 10-20% at diagnosis, often lung
- Risk factors: family history, prior radiation exposure
Molecular / cytogenetics description
End of Thyroid gland > Papillary carcinoma > Papillary carcinoma in children
- RET rearrangements more common than adults, BRAF activation less common (20% versus 77% in adults,
Mod Pathol 2005;18:898)
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