Thyroid gland
Benign neoplasms
Rosai-Dorfman disease

Author: Shahidul Islam, M.D., Ph.D. (see Authors page)

Revised: 27 January 2017, last major update March 2009

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PubMed Search: Rosai-Dorfman disease thyroid
Cite this page: Rosai-Dorfman disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/thyroidrosaidorf.html. Accessed October 19th, 2017.
Definition / general
  • Rare, < 15 cases reported in thyroid gland
  • Histiocytic proliferative disorder of unknown cause, mean age 21 years
Terminology
  • Also called sinus histiocytosis with massive lymphadenopathy
Clinical features
  • Typically presents with bilateral, painless cervical lymphadenopathy, although extranodal disease of head and neck is common
  • May represent extension from lymph node
  • Usually undergoes spontaneous remission after a protracted course, but may recur and rarely involves vital organs causing death
  • Associated with autoimmune thyroiditis (Thyroid 2007;17:471)
Case reports
Microscopic (histologic) description
  • Numerous histiocytes with abundant clear to eosinophilic cytoplasm and vesicular nuclei, also sheets of lymphocytes and plasma cells with emperipolesis (phagocytosis of intact lymphocytes and plasma cells)
Microscopic (histologic) images

Images hosted on other servers:

Various images

Negative stains
Differential diagnosis