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Thyroid gland
Other carcinoma
SETTLE

Reviewer: Shahidul Islam, M.D., Ph.D. (see Reviewers page)
Revised: 13 June 2013, last major update March 2009
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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Case reports
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Gross description
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Gross images
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Gray-tan tumor with vaguely lobular pattern
Micro description
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Micro images
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Left: irregular fibrous bands, right: invasive tumor entraps normal thyroid follicles
Fascicles of spindle cells merge with tubulopapillary structures
Streaming spindle cells have oval vesicular nuclei
Spindled cells with mesenchymal appearance (AFIP)
Metastatic tumor to lung
Pan keratin stains spindle cells diffusely

Fig 1: Cut surface is white and lobulated by fibrous capsule
Fig 2: Highly cellular with fascicles of spindle cells separated by stroma
Fig 3: Small foci of tubulopapillary epithelial cells
Fig 4: Tumor cells are strongly pancytokeratin+
Cytology description
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Positive stains
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Negative stains
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Differential diagnosis
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End of Thyroid gland > Other carcinoma > SETTLE


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