Thyroid gland
Silent thyroiditis

Author: Shahidul Islam, M.D., Ph.D. (see Authors page)

Revised: 13 January 2017, last major update March 2009

Copyright: (c) 2003-2017,, Inc.

PubMed Search: silent thyroiditis
Cite this page: Silent thyroiditis. website. Accessed July 23rd, 2018.
Definition / general
  • Transient, painless hyperthyroidism that spontaneously resolves
  • Also called painless or sometimes chronic lymphocytic thyroiditis
  • Relatively uncommon; usually women
  • Cause unknown, although hyperfunction is due to destruction of thyroid follicles
Clinical features
  • Elevated T3 / T4, low radioactive iodine uptake
Case reports
  • Usually none, beta blockers possibly in hyperthyroid phase
Gross description
  • Diffuse goiter or slightly enlarged thyroid gland
Microscopic (histologic) description
  • Preserved lobular pattern with follicular destruction, variable lymphocytic infiltrate, rare / no oncocytic change, no / focal fibrosis
  • T cells present in paracortex, B cells predominate in germinal center
Microscopic (histologic) images

Images hosted on other servers:

Mild lymphocytic infiltrate (Fig 1b)

Differential diagnosis