Thyroid gland
Other malignancies

Topic Completed: 1 July 2015

Minor changes: 18 March 2019

Copyright: 2015-2017,, Inc.

PubMed Search: teratoma thyroid

Sheren Younes, M.D.
Page views in 2019: 482
Page views in 2020 to date: 253
Cite this page: Younes S. Teratoma. website. Accessed July 8th, 2020.
Definition / general
  • Teratoma is a germ cell tumor characterized by the presence of 3 germ cell layers: ectoderm, endoderm and mesoderm
  • Common in newborns and infants (usually benign), rare in adolescence, usually malignant in adults (Cancer 2000;88:1149)
Clinical features
  • Thyroid mass, usually normal thyroid function
Radiology images

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Heterogeneously hypoechoic nodule

Large cystic fat-containing mass

Case reports
Gross description
  • Usually cystic
Gross images

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Well encapsulated, mixed solid and cystic mass

Lymph node involvement

Microscopic (histologic) description
  • Neuro / ectodermal tissue: squamous epithelium, glial tissue
  • Endodermal tissue: GI epithelium, thyroid and salivary glands
  • Mesodermal tissue: bone and cartilage
  • Presence of immature tissue or neuroepithelium makes it a malignant immature teratoma (Am J Surg Pathol 2005;29:700)
Microscopic (histologic) images

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Newborn infant (AFIP)

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Benign thyroid teratoma


Primitive neuroepithelial cells

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