Thyroid gland
Papillary carcinoma
Warthin-like variant

Authors: Shahidul Islam, M.D., Ph.D. (see Authors page)

Revised: 14 February, last major update March 2009

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Warthin-like variant thyroid
Cite this page: Warthin-like variant. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/thyroidwarthin.html. Accessed February 25th, 2017.
Definition / General
  • Features of oncocytic variant of papillary carcinoma plus brisk lymphoplasmacytic infiltrate in papillary stalks
  • Rare, usually women, resembles the salivary gland tumor
  • Usually no nodal or distant metastases (Ear Nose Throat J 2006;85:56)
  • Similar behavior to classic papillary carcinoma (Arch Pathol Lab Med 2000;124:1192)
Case Reports
  • 44 year old woman with 5 year history of diffuse multinodular goiter with enlarging thyroid gland (Case of the Week #386)
Gross Description
  • Tumors usually 2 cm or smaller
Micro Description
  • Circumscribed, papillary, centrally cystic, cells have oncocytic cytoplasm, papillary nuclear features; brisk lymphoplasmacytic infiltrate in papillary stalks
Micro Images

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Images hosted on PathOut server:

Contributed by Andrey Bychkov, M.D., Ph.D.:

Enlarged papillae

Lymphoid follicle with germinal center

Oncocytic epithelium and dense lymphocytic infiltration

Background Hashimoto thyroiditis



Case of the Week #386:





Images hosted on other servers:

Various images

Prominent chronic inflammatory infiltrate

Fig. 5: prominent lymphoplasmacytic stromal infiltrate

Cytology Description
  • Cellular smears with Hürthle cells in 3-dimensional groups, papillary fragments and as single cells with prominent lymphocytes and occasional plasma cells; Hürthle cells have granular eosinophilic cytoplasm, eccentric and pleomorphic nuclei and prominent nucleoli; papillary carcinoma nuclear features are present (Endocr Pathol 1998;9:317)
Molecular / Cytogenetics Description