Thyroid gland
Papillary carcinoma
Warthin-like variant

Topic Completed: 1 March 2009

Minor changes: 12 May 2020

Copyright: 2003-2020,, Inc.

PubMed Search: Warthin-like variant thyroid

Shahid Islam, M.D., Ph.D.
Page views in 2019: 2,112
Page views in 2020 to date: 889
Cite this page: Islam S. Warthin-like variant. website. Accessed June 1st, 2020.
Definition / general
  • Features of oncocytic variant of papillary carcinoma plus brisk lymphoplasmacytic infiltrate in papillary stalks
  • Rare, usually women, resembles the salivary gland tumor
  • Usually no nodal or distant metastases (Ear Nose Throat J 2006;85:56)
  • Similar behavior to classic papillary carcinoma (Arch Pathol Lab Med 2000;124:1192)
Gross description
  • Tumors usually 2 cm or smaller
Microscopic (histologic) description
  • Circumscribed, papillary, centrally cystic, cells have oncocytic cytoplasm, papillary nuclear features; brisk lymphoplasmacytic infiltrate in papillary stalks
Microscopic (histologic) images

Contributed by Andrey Bychkov, M.D., Ph.D.

Enlarged papillae

Lymphoid follicle with germinal center

epithelium and
dense lymphocytic

Background Hashimoto thyroiditis

Images hosted on other servers:

Various images

Prominent chronic inflammatory infiltrate

Prominent lymphoplasmacytic stromal infiltrate

Cytology description
  • Cellular smears with Hürthle cells in 3-dimensional groups, papillary fragments and as single cells with prominent lymphocytes and occasional plasma cells; Hürthle cells have granular eosinophilic cytoplasm, eccentric and pleomorphic nuclei and prominent nucleoli; papillary carcinoma nuclear features are present (Endocr Pathol 1998;9:317)
Molecular / cytogenetics description
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