Granular cell tumor

Author: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 15 November 2017, last major update October 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Trachea granular cell tumor

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Cite this page: Handra-Luca, A. Granular cell tumor. website. Accessed March 25th, 2019.
Definition / general
  • Benign tumor of possible neurogenic origin, rare in trachea, with solid sheets of large ovoid cells with ample, eosinophilic cytoplasm, eccentric nuclei and prominent nucleoli (Ann Otol Rhinol Laryngol 1984;93:457)
  • Luminal or secondarily involved; usually upper third of trachea
  • Adults, children, may be associated with pregnancy
  • May be incidental findings associated with lung and nodal tuberculosis, bronchial carcinoma (Orv Hetil 2002;143:239)
  • Clinically appears as yellowish patch
  • May rarely be malignant and invade retrotracheal space
Case reports
Microscopic (histologic) images

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20 year old man
with hemoptysis, cough
and pleuritic chest pain

Positive stains
Electron microscopy description
  • Progressive cytoplasmic granulation of cells, with transition from "early granular cells" to fully developed mature granular cells (Arch Pathol Lab Med 1987;111:1065)
Differential diagnosis
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