Granular cell tumor

Topic Completed: 1 October 2012

Revised: 5 April 2019

Copyright: 2002-2017,, Inc.

PubMed Search: Trachea granular cell tumor

Adriana Handra-Luca, M.D.
Page views in 2019: 114
Page views in 2020 to date: 9
Cite this page: Handra-Luca A. Granular cell tumor. website. Accessed January 23rd, 2020.
Definition / general
  • Benign tumor of possible neurogenic origin, rare in trachea, with solid sheets of large ovoid cells with ample, eosinophilic cytoplasm, eccentric nuclei and prominent nucleoli (Ann Otol Rhinol Laryngol 1984;93:457)
  • Luminal or secondarily involved; usually upper third of trachea
  • Adults, children, may be associated with pregnancy
  • May be incidental findings associated with lung and nodal tuberculosis, bronchial carcinoma (Orv Hetil 2002;143:239)
  • Clinically appears as yellowish patch
  • May rarely be malignant and invade retrotracheal space
Case reports
Microscopic (histologic) images

Images hosted on other servers:

20 year old man
with hemoptysis, cough
and pleuritic chest pain

Positive stains
Electron microscopy description
  • Progressive cytoplasmic granulation of cells, with transition from "early granular cells" to fully developed mature granular cells (Arch Pathol Lab Med 1987;111:1065)
Differential diagnosis
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