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Trachea

Tumors

Mucoepidermoid carcinoma


Reviewer: Adriana Handra-Luca, M.D. (see Reviewers page)
Revised: 8 February 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.

General
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● Usually low grade lesion with squamous cells without atypia in desmoplastic stroma

Clinical features
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● Usually children with a luminal polyp, possibly with bronchus extension
● May occur in patients with tracheobronchopathia osteochondroplastica
● Symptoms: dyspnea, stridor

Case reports
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● 9 year old boy with dyspnea and diaphoresis (Interact Cardiovasc Thorac Surg 2012;15:311)
● 11 year old girl with dedifferentiated tumor (Histopathology 2009;55:472)
● 22 year old woman with exertional dyspnea and stridor (Pneumologia 2011;60:164)
● 51 year old man with tracheobronchopathia osteochondroplastica (Chirurg 1995;66:231)
● 78 year old woman with oncocytic tumor (Arch Pathol Lab Med 1999;123:635)

Treatment
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● Resection

Micro description
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● Low grade lesion with foci of squamous differentiation without atypia in desmoplastic stroma
● Prominent vascular component
● No marked atypia, no necrosis, no mitotic activity, no angiolymphatic invasion, may be dedifferentiated

Micro images
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9 year old boy


Oncocytic tumor: simple cysts, oncocytes and anti-mitochondrial antibody

Positive stains
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● Keratin (entire tumor)
● Oncocytic tumor: PTAH and antimitochondrial antibody in oncocytes

Negative stains
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● Neuroendocrine markers, Congo red

Differential diagnosis
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● Carcinoid tumor

End of Trachea > Tumors > Mucoepidermoid carcinoma


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