Mucous membrane plasmacytosis

Trachea
Nonneoplastic lesions
Mucous membrane plasmacytosis

Author: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 13 November 2017, last major update October 2012

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PubMed Search: Mucous membrane plasmacytosis

Table of Contents

Definition / general | Treatment | Gross description | Microscopic (histologic) description | Microscopic (histologic) images

Cite this page: Handra-Luca, A. Mucous membrane plasmacytosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/tracheamucousmembraneplasma.html. Accessed April 24th, 2018.

Definition / general

Nonneoplastic proliferative disorder of plasma cells
Mean 54 years, range 40 - 67 years, 2/3 men

Treatment

Unknown: antibiotics, steroids, surgery are unsuccessful

Gross description

Cobblestone or warty appearance of larynx, pharynx, palate, lips, mouth, tongue, trachea

Microscopic (histologic) description

Psoriasiform epithelial hyperplasia with dyskeratosis and dense subepithelial plasmacytosis
Diffuse but mature plasma cells are polyclonal (i.e. no light chain restriction)

Microscopic (histologic) images

Images hosted on other servers:

Buccal mucosa: hyperplastic, parakeratinized
stratified squamous epithelium with
dense infiltrate of mature
plasma cells in lamina propria

Buccal mucosa: plasma
cells are IgG+, CD138+,
both kappa+ and lambda+