Nonneoplastic lesions
Mucous membrane plasmacytosis

Author: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 13 November 2017, last major update October 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Mucous membrane plasmacytosis

Cite this page: Handra-Luca, A. Mucous membrane plasmacytosis. website. Accessed April 24th, 2018.
Definition / general
  • Nonneoplastic proliferative disorder of plasma cells
  • Mean 54 years, range 40 - 67 years, 2/3 men
  • Unknown: antibiotics, steroids, surgery are unsuccessful
Gross description
  • Cobblestone or warty appearance of larynx, pharynx, palate, lips, mouth, tongue, trachea
Microscopic (histologic) description
  • Psoriasiform epithelial hyperplasia with dyskeratosis and dense subepithelial plasmacytosis
  • Diffuse but mature plasma cells are polyclonal (i.e. no light chain restriction)
Microscopic (histologic) images

Images hosted on other servers:

Buccal mucosa: hyperplastic, parakeratinized
stratified squamous epithelium with
dense infiltrate of mature
plasma cells in lamina propria

Buccal mucosa: plasma
cells are IgG+, CD138+,
both kappa+ and lambda+