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Non-neoplastic lesions

Mucous membrane plasmacytosis

Reviewer: Adriana Handra-Luca, M.D. (see Reviewers page)
Revised: 4 February 2013, last major update October 2012
Copyright: (c) 2003-2013, PathologyOutlines.com, Inc.


● Non-neoplastic proliferative disorder of plasma cells
● Mean 54 years, range 40-67 years, 2/3 men


● Unknown: antibiotics, steroids, surgery are unsuccessful

Gross description

● Cobblestone or warty appearance of larynx, pharynx, palate, lips, mouth, tongue, trachea

Micro description

● Psoriasiform epithelial hyperplasia with dyskeratosis and dense subepithelial plasmacytosis
● Diffuse but mature plasma cells are polyclonal (i.e. no light chain restriction)

Micro images

Buccal mucosa: hyperplastic, parakeratinized stratified squamous epithelium with dense infiltrate of mature plasma cells in lamina propria

Buccal mucosa: plasma cells are IgG+, CD138+, both kappa+ and lambda+

End of Trachea > Non-neoplastic lesions > Mucous membrane plasmacytosis

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