Table of Contents
Definition / general | Clinical features | Case reports | Treatment | Microscopic (histologic) description | Differential diagnosisCite this page: Handra-Luca A. Papilloma / papillomatosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/tracheapapilloma.html. Accessed April 19th, 2019.
Definition / general
- Benign squamous lesion similar to laryngeal lesions, due to infection with HPV6, HPV11 (Chron Respir Dis 2011;8:233, J Med Virol 2004;72:473)
Clinical features
- Juvenile and adult onset
- Symptoms: cough, hemophtysis
- May disappear spontaneously
- May occur in patient with primary biliary cirrhosis, Cowden disease, tuberculosis
- Cases associated with laryngeal lesions have low incidence of malignant transformation
- Cases limited to trachea and bronchi usually begin in adults, have higher incidence of malignant transformation
- Tracheotomy is associated with progression of laryngeal papilloma into trachea (Zhonghua Er Bi Yan Hou Ke Za Zhi 2000;35:384)
Case reports
- 27 year old man with large papillary mass and invasive component (Am J Surg Pathol 1980;4:79)
- 42 year old woman with multiple papillomatous-like tumors involving the trachea and bronchi (Chest 1983;83:817)
- 52 year old woman with breathlessness on exertion (Ann Thorac Surg 2004;77:2201)
- 57 year old man with malignant transformation of solitary papilloma (Can Respir J 2008;15:375)
- 58 year old man with Cowden disease (Intern Med 2006;45:987)
- 66 year old man with recurrent papilloma (Asian J Surg 2007;30:88)
- 72 year old woman with multiple squamous papillomas (Intern Med 2008;47:1535)
Treatment
- HPV vaccine (to prevent); medical therapy, multiple surgery if recurrence
Microscopic (histologic) description
- Usually benign squamous, intermediate and ciliated cells overlying fibrovascular stroma
- Invasive tumor may have intracystic papillary structures, atypical invasive epithelium
Differential diagnosis
- Oat cell carcinoma: looks similar at bronchoscopy
