Papilloma / papillomatosis

Trachea
Tumors
Papilloma / papillomatosis

Author: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 16 November 2017, last major update October 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Trachea papilloma papillomatosis [title]

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Table of Contents

Cite this page: Handra-Luca, A. Papilloma / papillomatosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/tracheapapilloma.html. Accessed January 23rd, 2019.

Definition / general

Benign squamous lesion similar to laryngeal lesions, due to infection with HPV6, HPV11 (Chron Respir Dis 2011;8:233, J Med Virol 2004;72:473)

Clinical features

Juvenile and adult onset
Symptoms: cough, hemophtysis
May disappear spontaneously
May occur in patient with primary biliary cirrhosis, Cowden disease, tuberculosis
Cases associated with laryngeal lesions have low incidence of malignant transformation
Cases limited to trachea and bronchi usually begin in adults, have higher incidence of malignant transformation
Tracheotomy is associated with progression of laryngeal papilloma into trachea (Zhonghua Er Bi Yan Hou Ke Za Zhi 2000;35:384)

Case reports

27 year old man with large papillary mass and invasive component (Am J Surg Pathol 1980;4:79)
42 year old woman with multiple papillomatous-like tumors involving the trachea and bronchi (Chest 1983;83:817)
52 year old woman with breathlessness on exertion (Ann Thorac Surg 2004;77:2201)
57 year old man with malignant transformation of solitary papilloma (Can Respir J 2008;15:375)
58 year old man with Cowden disease (Intern Med 2006;45:987)
66 year old man with recurrent papilloma (Asian J Surg 2007;30:88)
72 year old woman with multiple squamous papillomas (Intern Med 2008;47:1535)

Treatment

HPV vaccine (to prevent); medical therapy, multiple surgery if recurrence

Microscopic (histologic) description

Usually benign squamous, intermediate and ciliated cells overlying fibrovascular stroma
Invasive tumor may have intracystic papillary structures, atypical invasive epithelium

Differential diagnosis

Oat cell carcinoma: looks similar at bronchoscopy