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Table of Contents
Definition / general | Clinical features | Case reports | Treatment | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosisCite this page: Handra-Luca, A. Squamous cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/tracheascc.html. Accessed January 23rd, 2019.
Definition / general
- Exophytic, obstructive tumor usually in smokers (J Am Coll Surg 2006;202:237) but also children
- Most common primary malignancy of trachea (40 - 75%, Cancer 1990;66:894)
Clinical features
- Usually arises in lower third of trachea (Eur Arch Otorhinolaryngol 1993;250:383, Acta Otolaryngol 1991;111:1162)
- May be extension of other head and neck primary
- May be associated with pneumoconiosis or posttracheotomy scar (Respiration 1993;60:250)
- Rapid clinical course, poor prognosis (Am J Clin Oncol 2011;34:32, Virchows Arch 2009;455:423, Jpn J Clin Oncol 1997;27:305)
Case reports
- 11 month old boy with severe dyspnea and stridor (Int J Pediatr Otorhinolaryngol 1998;43:163)
- 37 year old woman with hypohidrotic ectodermal dysplasia (J Laryngol Otol 2002;116:742)
- 50 year old man with unresectable basaloid squamous cell carcinoma (J Cancer Res Ther 2010;6:321)
- 52 year old woman with HPV and squamous cell carcinoma in a solitary tracheal papilloma (Ann Thorac Surg 2004;77:2201)
- 54 year old man with dyspnea, hemoptysis, cough and weight loss (Acta Otorhinolaryngol Ital 2010;30:209)
- 70 year old woman with double primary cancer of the lung and trachea (Nihon Kyobu Shikkan Gakkai Zasshi 1996;34:216)
- 78 year old man with spindle cell sarcomatoid carcinoma (Tuberk Toraks 2009;57:337)
Treatment
- Surgical excision with end to end anastomosis, radiation therapy (Med Princ Pract 2004;13:69)
Microscopic (histologic) description
- Variants include spindle cell, sarcomatoid
- May arise in papilloma
- May be combined with small cell and giant cell carcinoma
Microscopic (histologic) images
Images hosted on other servers:
Basaloid squamous cell carcinoma
Various images
Differential diagnosis
- Adenoid cystic carcinoma
- Extension of esophageal tumor (Arch Pathol Lab Med 1984;108:983)
- Metastasis from colon carcinoma (Can Assoc Radiol J 1989;40:198)
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