Trachea
Tumors
Small cell carcinoma

Author: Adriana Handra-Luca, M.D. (see Authors page)

Revised: 6 December 2017, last major update October 2012

Copyright: (c) 2002-2017, PathologyOutlines.com, Inc.

PubMed Search: Small cell carcinoma trachea [title]

Cite this page: Handra-Luca, A. Small cell carcinoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/tracheasmallcell.html. Accessed December 14th, 2017.
Definition / general
  • Histology similar to bronchial tumor
  • 6% of primary tracheal tumors in 1993 study (Thorax 1993;48:688)
Clinical features
  • Endotracheal nodule or eccentric wall thickening, papillomatous at endoscopy
  • May be tracheobronchic
  • May occur with hypophosphatemia osteomalacia and Cushing syndrome
  • May occur secondary to breast ductal carcinoma with radiation or be metastatic from lung primary
  • May metastasize to CNS
Case reports
Treatment
Microscopic (histologic) description
  • Classic features of large neuroendocrine cells with high N/C ratio, hyperchromatic nuclei, crush artifact, nuclear molding
  • May show combined morphology with squamous cell carcinoma and giant cell carcinoma
Microscopic (histologic) images

Images hosted on other servers:

Adjacent islands of oat cell and
squamous cell carcinoma surrounded
by stroma containing bizarre giant
cells (haematoxylin and eosin x500)

Esophagus: small cell carcinoma, oat cell type

Positive stains
Differential diagnosis
  • Extension from bronchial tumor