Small cell carcinoma

Topic Completed: 1 October 2012

Revised: 5 April 2019

Copyright: 2002-2017,, Inc.

PubMed Search: Small cell carcinoma trachea [title]

Adriana Handra-Luca, M.D.
Page views in 2018: 46
Page views in 2019 to date: 46
Cite this page: Handra-Luca A. Small cell carcinoma. website. Accessed October 22nd, 2019.
Definition / general
  • Histology similar to bronchial tumor
  • 6% of primary tracheal tumors in 1993 study (Thorax 1993;48:688)
Clinical features
  • Endotracheal nodule or eccentric wall thickening, papillomatous at endoscopy
  • May be tracheobronchic
  • May occur with hypophosphatemia osteomalacia and Cushing syndrome
  • May occur secondary to breast ductal carcinoma with radiation or be metastatic from lung primary
  • May metastasize to CNS
Case reports
Microscopic (histologic) description
  • Classic features of large neuroendocrine cells with high N/C ratio, hyperchromatic nuclei, crush artifact, nuclear molding
  • May show combined morphology with squamous cell carcinoma and giant cell carcinoma
Microscopic (histologic) images

Images hosted on other servers:

Adjacent islands of oat cell and
squamous cell carcinoma surrounded
by stroma containing bizarre giant
cells (haematoxylin and eosin x500)

Esophagus: small cell carcinoma, oat cell type

Positive stains
Differential diagnosis
  • Extension from bronchial tumor
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