CMV and transfusion
Reviewer: Huy Phu Pham, M.D. (see Reviewers page)
Revised: 1 November 2011, last major update October 2011
Copyright: (c) 2007-2011, PathologyOutlines.com, Inc.
● 50%-85% of US population is CMV+; 50% of US donors are CMV seropositive, compared to 93% in Ghana (Ghana Med J 2006;40:99)
● Seroconversion rate is 1% per year
● CMV is almost always latent in immunocompetent adults; CMV virus is latent in leukocytes
● Leukoreduction reduces risk of CMV transmission
● Leukoreduced blood products are generally considered equivalent to CMV negative products
● CMV can cause pneumonitis, hepatitis, retinitis or organ failure in immunocompromised recipients, who should get CMV negative or leukoreduced blood components (Bone Marrow Transplant 2005;36:499, Transfus Med Rev 2005;19:181)
End of Transfusion Medicine > Tranfusion-transmitted disease > CMV and transfusion
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