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Transfusion medicine

Tranfusion-transmitted disease

Trypanosoma cruzi (Chagas’ disease)

Reviewer: Huy Phu Pham, M.D. (see Reviewers page)
Revised: 6 November 2011, last major update October 2011
Copyright: (c) 2007-2011, PathologyOutlines.com, Inc.

General
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● Chagas’ disease is confined mainly to Mexico and South America
● 50-100K chronic carriers in US, due to immigration
● Transmitted to humans through bite of reduvid bugs
● Canada to start screening in 2008 (CMAJ 2007;177:242)
● FDA licensed a screening test for antibodies to T. cruzi in blood donors in 2006; Red Cross and other blood collection centers are screening in US
● Photoinactivation may be useful for red cell suspensions (Transfus Apher Sci 2007;37:23), platelets (Transfusion 2007;47:434) or plasma (Vox Sang 006;91:285)

Donor/control positive rates:
● Brazil - 2% (Rev Soc Bras Med Trop 2006;39:530)
● Columbia - 0.4% (Biomedica 2005;25:527)
● Mexico - 0.5% (Salud Publica Mex 2006;48:13)
● US high risk regions - 1 per 5000 (MMWR Morb Mortal Wkly Rep 2007;56:141)

Case reports
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● Transfusion from Bolivian blood donor to US child (Transfusion 2007;47:540)

End of Transfusion Medicine > Tranfusion-transmitted disease > Trypanosoma cruzi (Chagas’ disease)

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